DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jusuk Lee | - |
dc.contributor.author | Yeonock Oh | - |
dc.contributor.author | Yoon Kyung Choi | - |
dc.contributor.author | Eunjeong Choi | - |
dc.contributor.author | Kyungwoo | - |
dc.contributor.author | Park, J | - |
dc.contributor.author | KIM, MAHN JOO | - |
dc.date.accessioned | 2016-04-01T08:06:50Z | - |
dc.date.available | 2016-04-01T08:06:50Z | - |
dc.date.created | 2015-02-12 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 2155-5435 | - |
dc.identifier.other | 2015-OAK-0000030738 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27249 | - |
dc.description.abstract | We explored the kinetic resolution of 31 different diarylmethanols with an activated lipoprotein lipase (LPL-D1) which was about 3000-fold more active than its native counterpart in organic solvent. Most of the substrates tested were accepted by LPL-D1 with good to high enantioselectivity in the kinetic resolution. Next, we explored the dynamic kinetic resolutions (DKRs) of these substrates (24 out of 31) using LPL-D1 and a ruthenium-based racemization catalyst in combination, which provided satisfactory yields (71-96%) and high enantiopurities (90-99% cc). As an illustrative example for the synthetic applications of the DKR procedure, we synthesized L-cloperastine, an antitussive drug, from phenyl-(p-trimethylsilylphenyl)methanol via DKR. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS CATALYSIS | - |
dc.title | Dynamic Kinetic Resolution of Diarylmethanols with an Activated Lipoprotein Lipase | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1021/CS501629M | - |
dc.author.google | Lee, J | - |
dc.author.google | Oh, Y | - |
dc.author.google | Choi, YK | - |
dc.author.google | Choi, E | - |
dc.author.google | Kim, K | - |
dc.author.google | Park, J | - |
dc.author.google | Kim, MJ | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 683 | - |
dc.relation.lastpage | 689 | - |
dc.contributor.id | 10075891 | - |
dc.relation.journal | ACS CATALYSIS | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS CATALYSIS, v.5, no.2, pp.683 - 689 | - |
dc.identifier.wosid | 000349275300023 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 689 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 683 | - |
dc.citation.title | ACS CATALYSIS | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Park, J | - |
dc.contributor.affiliatedAuthor | KIM, MAHN JOO | - |
dc.identifier.scopusid | 2-s2.0-84922796530 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BURKHOLDERIA-CEPACIA LIPASE | - |
dc.subject.keywordPlus | SECONDARY ALCOHOLS | - |
dc.subject.keywordPlus | CATALYTIC RACEMIZATION | - |
dc.subject.keywordPlus | ENZYMATIC RESOLUTION | - |
dc.subject.keywordPlus | ASYMMETRIC-SYNTHESIS | - |
dc.subject.keywordPlus | MESOPOROUS-SILICA | - |
dc.subject.keywordPlus | RUTHENIUM | - |
dc.subject.keywordPlus | METAL | - |
dc.subject.keywordPlus | HYDROGENATION | - |
dc.subject.keywordPlus | KETOXIMES | - |
dc.subject.keywordAuthor | diarylmethanol | - |
dc.subject.keywordAuthor | dynamic kinetic resolution | - |
dc.subject.keywordAuthor | lipase | - |
dc.subject.keywordAuthor | ruthenium | - |
dc.subject.keywordAuthor | catalysis | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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