DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yongwook Choi | - |
dc.contributor.author | KIM, JONG KYOUNG | - |
dc.contributor.author | Yoo, JY | - |
dc.date.accessioned | 2016-04-01T08:07:56Z | - |
dc.date.available | 2016-04-01T08:07:56Z | - |
dc.date.created | 2014-07-25 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1574-7891 | - |
dc.identifier.other | 2014-OAK-0000030088 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27292 | - |
dc.description.abstract | Chronic inflammation is one of the main causes of cancer, yet the molecular mechanism underlying this effect is not fully understood. In this study, we identified FAT10 as a potential target gene of STAT3, the expression of which is synergistically induced by NF kappa B co-stimulation. STAT3 binding stabilizes NF kappa B on the FAT10 promoter and leads to maximum induction of FAT10 gene expression. Increased FAT10 represses the transcriptional activity of the tumor suppressor p53, a protein that accelerates the protein degradation of FAT10. This FAT10-p53 double-negative regulation is critical in the control of tumorigenesis, as overexpressed FAT10 facilitates the tumor progression in the solid tumor model. In conclusion, transcriptional synergy between STAT3 and NF kappa B functions to put weight on FAT10 in the mutually inhibitory FAT10-p53 regulatory loop and thus favors tumorigenesis under inflammatory conditions. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.relation.isPartOf | Molecular Oncology | - |
dc.title | NF kappa B and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53 | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.MOLONC.2014.01.007 | - |
dc.author.google | Choi Y. | - |
dc.author.google | Kim J.K. | - |
dc.author.google | Yoo J.-Y. | - |
dc.relation.volume | 8 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 642 | - |
dc.relation.lastpage | 655 | - |
dc.contributor.id | 10114821 | - |
dc.relation.journal | MOLECULAR ONCOLOGY | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Molecular Oncology, v.8, no.3, pp.642 - 655 | - |
dc.identifier.wosid | 000336472100017 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 655 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 642 | - |
dc.citation.title | Molecular Oncology | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | KIM, JONG KYOUNG | - |
dc.contributor.affiliatedAuthor | Yoo, JY | - |
dc.identifier.scopusid | 2-s2.0-84899493959 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROINFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | IL-6 | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | FAT10 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Tumorigenesis | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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