DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JK | - |
dc.contributor.author | Yeom, J | - |
dc.contributor.author | Oh, EJ | - |
dc.contributor.author | Reddy, M | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Cho, DW | - |
dc.contributor.author | Lim, HP | - |
dc.contributor.author | Kim, NS | - |
dc.contributor.author | Park, SW | - |
dc.contributor.author | Shin, HI | - |
dc.contributor.author | Yang, DJ | - |
dc.contributor.author | Park, KB | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-04-01T08:17:17Z | - |
dc.date.available | 2016-04-01T08:17:17Z | - |
dc.date.created | 2009-12-08 | - |
dc.date.issued | 2009-11 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.other | 2009-OAK-0000019747 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27637 | - |
dc.description.abstract | A novel protocol for the synthesis of biocompatible and degradation controlled poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) was successfully developed for periodontal barrier applications. HA was chemically modified with adipic acid dihydrazide (ADH) in the mixed solvent of water and ethanol, which resulted in a high degree of HA modification up to 85 mol.%. The stability of HA-ADH to enzymatic degradation by hyaluronidase increased with ADH content in HA-ADH. When the ADH content in HA-ADH was higher than 80 mol.%, HA-ADH became soluble in dimethyl sulfoxide and could be grafted to the activated PLGA with N,N'-dicyclohexyl carbodiimide and N-hydroxysuccinimide. The resulting HA-PLGA was used for the preparation of biphasic periodontal barrier membranes in chloroform. According to in vitro hydrolytic degradation tests in phosphate buffered saline, HA-PLGA/PLGA blend film with a weight ratio of 1/2 degraded relatively slowly compared to PLGA film and HA coated PLGA film. Four different sa I triples of a control, OSSIX (TM) membrane, PLGA film, and HA-PLGA/PLGA film were assessed as periodontal barrier membranes for the calvarial critical size bone defects in SD rats. Histological and histomorphometric analyses revealed that HA-PLGA/PLGA film resulted in the most effective bone regeneration compared to other samples with a regenerated bone area of 63.1% covering the bone defect area. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | ACTA BIOMATERIALIA | - |
dc.subject | Hyaluronic acid | - |
dc.subject | Poly(lactic-co-glycolic acid) | - |
dc.subject | Periodontal barrier membrane | - |
dc.subject | Controlled degradation | - |
dc.subject | Bone regeneration | - |
dc.subject | SUSTAINED-RELEASE FORMULATION | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | COLLAGEN MEMBRANE | - |
dc.subject | IN-VIVO | - |
dc.subject | ATTACHMENT FORMATION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | DEFECTS | - |
dc.subject | HYDROGELS | - |
dc.title | Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/j.actbio.2009.05.019 | - |
dc.author.google | Park, JK | - |
dc.author.google | Yeom, J | - |
dc.author.google | Oh, EJ | - |
dc.author.google | Reddy, M | - |
dc.author.google | Kim, JY | - |
dc.author.google | Cho, DW | - |
dc.author.google | Lim, HP | - |
dc.author.google | Kim, NS | - |
dc.author.google | Park, SW | - |
dc.author.google | Shin, HI | - |
dc.author.google | Yang, DJ | - |
dc.author.google | Park, KB | - |
dc.author.google | Hahn, SK | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 9 | - |
dc.relation.startpage | 3394 | - |
dc.relation.lastpage | 3403 | - |
dc.contributor.id | 10102903 | - |
dc.relation.journal | ACTA BIOMATERIALIA | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACTA BIOMATERIALIA, v.5, no.9, pp.3394 - 3403 | - |
dc.identifier.wosid | 000271853300011 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3403 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3394 | - |
dc.citation.title | ACTA BIOMATERIALIA | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-66949116346 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 37 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE FORMULATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ATTACHMENT FORMATION | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | COLLAGEN MEMBRANE | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Poly(lactic-co-glycolic acid) | - |
dc.subject.keywordAuthor | Periodontal barrier membrane | - |
dc.subject.keywordAuthor | Controlled degradation | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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