DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, B | - |
dc.contributor.author | Kim, KH | - |
dc.contributor.author | So, PTC | - |
dc.contributor.author | Blankschtein, D | - |
dc.contributor.author | Langer, R | - |
dc.date.accessioned | 2016-04-01T08:28:20Z | - |
dc.date.available | 2016-04-01T08:28:20Z | - |
dc.date.created | 2009-09-24 | - |
dc.date.issued | 2003-03 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.other | 2003-OAK-0000018953 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28050 | - |
dc.description.abstract | In a novel application of dual-channel high-speed two-photon fluorescence microscopy, the skin autofluorescence and the transdermal fluorescent model drug spatial distributions were imaged simultaneously over precisely the same spatial coordinates. The dual channels enable the detection of the fluorescence emission wavelengths characteristic of the endogenous (intrinsic) skin fluorophores, as well as of the rhodamine-based model drug intensity emission at a different wavelength range of the fluorescence emission spectrum. These fluorescent model drugs delineate the oleic acid induced changes in permeant diffusion with respect to the skin structural features over the 0.3 mm by 0.3 mm skin area imaged per skin sample. The dual-channel high-speed two-photon fluorescence microscopy studies presented here provide evidence for the existence of intracorneocyte diffusion in addition to the commonly cited lipid multilamellar transdermal pathway. The image quantification analysis methodology introduced in this paper reveals that intracorneocyte diffusion exists for the hydrophobic (rhodamine B hexyl ester) and for the hydrophilic (sulforhodamine B) model drugs, in the absence of oleic acid chemical enhancer action. The mechanism of oleic acid chemical enhancer action, however, depends on the model drug physicochemical properties, where the oleic acid induces hydrophobic model drug localization to the lipid multilamellar region, while increasing the hydrophilic model drug lipid to corneocyte partitioning. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | BLACKWELL PUBLISHING INC | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.subject | chemical enhancement mechanism | - |
dc.subject | dual-channel high-speed two-photon fluorescence microscopy | - |
dc.subject | oleic acid | - |
dc.subject | skin autofluorescence | - |
dc.subject | 2-PHOTON EXCITATION MICROSCOPY | - |
dc.subject | ENDOGENOUS SKIN FLUORESCENCE | - |
dc.subject | VIVO HUMAN SKIN | - |
dc.subject | STRATUM-CORNEUM | - |
dc.subject | STRUCTURAL MODIFICATIONS | - |
dc.subject | HIGH-SPEED | - |
dc.subject | PERMEATION | - |
dc.subject | AUTOFLUORESCENCE | - |
dc.subject | MODEL | - |
dc.subject | BANDS | - |
dc.title | Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy | - |
dc.type | Article | - |
dc.contributor.college | 기계공학과 | - |
dc.identifier.doi | 10.1046/j.1523-1747.2003.12061.x | - |
dc.author.google | Yu, B | - |
dc.author.google | Kim, KH | - |
dc.author.google | So, PTC | - |
dc.author.google | Blankschtein, D | - |
dc.author.google | Langer, R | - |
dc.relation.volume | 120 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 448 | - |
dc.relation.lastpage | 455 | - |
dc.contributor.id | 10183385 | - |
dc.relation.journal | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.120, no.3, pp.448 - 455 | - |
dc.identifier.wosid | 000181340000019 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 455 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 448 | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.volume | 120 | - |
dc.contributor.affiliatedAuthor | Kim, KH | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 71 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | 2-PHOTON EXCITATION MICROSCOPY | - |
dc.subject.keywordPlus | ENDOGENOUS SKIN FLUORESCENCE | - |
dc.subject.keywordPlus | VIVO HUMAN SKIN | - |
dc.subject.keywordPlus | STRATUM-CORNEUM | - |
dc.subject.keywordPlus | STRUCTURAL MODIFICATIONS | - |
dc.subject.keywordPlus | HIGH-SPEED | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | AUTOFLUORESCENCE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | BANDS | - |
dc.subject.keywordAuthor | chemical enhancement mechanism | - |
dc.subject.keywordAuthor | dual-channel high-speed two-photon fluorescence microscopy | - |
dc.subject.keywordAuthor | oleic acid | - |
dc.subject.keywordAuthor | skin autofluorescence | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
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