DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, SY | - |
dc.contributor.author | Zheng, T | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Cohn, L | - |
dc.contributor.author | Homer, RJ | - |
dc.contributor.author | McKenzie, ANJ | - |
dc.contributor.author | Zhu, Z | - |
dc.date.accessioned | 2016-04-01T08:33:23Z | - |
dc.date.available | 2016-04-01T08:33:23Z | - |
dc.date.created | 2009-08-25 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 1044-1549 | - |
dc.identifier.other | 2009-OAK-0000018466 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28241 | - |
dc.description.abstract | Asthma is a chronic inflammatory disorder of the airways. Type 2 T helper (Th) cell-dominated inflammation in the lung is a hallmark of asthma. Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 is a negative regulator in the signaling pathways of many growth factor and cytokine receptors. However, a direct role of SHP-1 in the IL-4/IL-13 signaling pathway has not been established. In this study, we sought to define the function of SHP-1 in the lung by characterizing the pulmonary inflammation of viable motheaten (mev) mice, and to investigate the molecular mechanisms involved. Pulmonary histology, physiology, and cytokine expression of mev mice were analyzed to define the nature of the inflammation, and the gene-deletion approach was used to identify critical molecules involved. In mev mice, we observed spontaneous Th2-like inflammatory responses in the lung, including eosinophilia, mucus metaplasia, airway epithelial hypertrophy, pulmonary fibrosis, and increased airway resistance and airway hyperresponsiveness. The pulmonary phenotype was accompanied by up-regulation of Th2 cytokines and chemokines. Selective deletion of IL-13 or signal transducer and activator of transcription 6, key genes in the Th2 signaling pathway, significantly reduced, but did not completely eliminate, the inflammation in the lung. These findings suggest that SHP-1 plays a critical role in regulating the IL-4/IL-13 signaling pathway and in maintaining lung homeostasis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER THORACIC SOC | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.subject | Src homology 2 domain-containing protein tyrosine phosphatase-1 | - |
dc.subject | protein tyrosine phosphatase | - |
dc.subject | motheaten mouse | - |
dc.subject | type 2 T helper cell inflammation | - |
dc.subject | lung | - |
dc.subject | TYROSINE-PHOSPHATASE SHP-1 | - |
dc.subject | ALLERGIC AIRWAY INFLAMMATION | - |
dc.subject | MOTH-EATEN | - |
dc.subject | INTERLEUKIN-4 RECEPTOR | - |
dc.subject | IMMUNODEFICIENT MUTANT | - |
dc.subject | IL-4 RECEPTOR | - |
dc.subject | MICE | - |
dc.subject | MOUSE | - |
dc.subject | HYPERRESPONSIVENESS | - |
dc.subject | MOTHEATEN | - |
dc.title | A CRITICAL ROLE OF SHP-1 IN REGULATION OF TYPE 2 INFLAMMATION IN THE LUNG | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1165/RCMB.2008-02 | - |
dc.author.google | Oh, SY | - |
dc.author.google | Zheng, T | - |
dc.author.google | Kim, YK | - |
dc.author.google | Cohn, L | - |
dc.author.google | Homer, RJ | - |
dc.author.google | McKenzie, ANJ | - |
dc.author.google | Zhu, Z | - |
dc.relation.volume | 40 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 568 | - |
dc.relation.lastpage | 574 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, v.40, no.5, pp.568 - 574 | - |
dc.identifier.wosid | 000265620300007 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 574 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 568 | - |
dc.citation.title | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Kim, YK | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 20 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TYROSINE-PHOSPHATASE SHP-1 | - |
dc.subject.keywordPlus | ALLERGIC AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | MOTH-EATEN | - |
dc.subject.keywordPlus | INTERLEUKIN-4 RECEPTOR | - |
dc.subject.keywordPlus | IMMUNODEFICIENT MUTANT | - |
dc.subject.keywordPlus | IL-4 RECEPTOR | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | MOTHEATEN | - |
dc.subject.keywordAuthor | Src homology 2 domain-containing protein tyrosine phosphatase-1 | - |
dc.subject.keywordAuthor | protein tyrosine phosphatase | - |
dc.subject.keywordAuthor | motheaten mouse | - |
dc.subject.keywordAuthor | type 2 T helper cell inflammation | - |
dc.subject.keywordAuthor | lung | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Respiratory System | - |
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