DC Field | Value | Language |
---|---|---|
dc.contributor.author | Si, K | - |
dc.contributor.author | Giustetto, M | - |
dc.contributor.author | Etkin, A | - |
dc.contributor.author | Hsu, R | - |
dc.contributor.author | Janisiewicz, AM | - |
dc.contributor.author | Miniaci, MC | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Zhu, HX | - |
dc.contributor.author | K | - |
dc.contributor.author | el, ER | - |
dc.date.accessioned | 2016-04-01T08:37:07Z | - |
dc.date.available | 2016-04-01T08:37:07Z | - |
dc.date.created | 2009-08-24 | - |
dc.date.issued | 2003-12-26 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | 2004-OAK-0000018248 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28382 | - |
dc.description.abstract | Synapse-specific facilitation requires rapamycin-dependent local protein synthesis at the activated synapse. In Aplysia, rapamycin-dependent local protein synthesis serves two functions: (1) it provides a component of the mark at the activated synapse and thereby confers synapse specificity and (2) it stabilizes the synaptic growth associated with long-term facilitation. Here we report that a neuron-specific isoform of cytoplasmic polyadenylation element binding protein (CPEB) regulates this synaptic protein synthesis in an activity-dependent manner. Aplysia CPEB protein is upregulated locally at activated synapses, and it is needed not for the initiation but for the stable maintenance of long-term facilitation. We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL | - |
dc.subject | XENOPUS OOCYTE MATURATION | - |
dc.subject | ELEMENT-BINDING PROTEIN | - |
dc.subject | CAMKII MESSENGER-RNA | - |
dc.subject | DROSOPHILA ORB GENE | - |
dc.subject | CYTOPLASMIC POLYADENYLATION | - |
dc.subject | TRANSLATIONAL CONTROL | - |
dc.subject | S6 KINASE | - |
dc.subject | EXPRESSION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | POTENTIATION | - |
dc.title | A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0092-8674(03)01021-3 | - |
dc.author.google | Si, K | - |
dc.author.google | Giustetto, M | - |
dc.author.google | Etkin, A | - |
dc.author.google | Hsu, R | - |
dc.author.google | Janisiewicz, AM | - |
dc.author.google | Miniaci, MC | - |
dc.author.google | Kim, JH | - |
dc.author.google | Zhu, HX | - |
dc.author.google | Kandel, ER | - |
dc.relation.volume | 115 | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 893 | - |
dc.relation.lastpage | 904 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | CELL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELL, v.115, no.7, pp.893 - 904 | - |
dc.identifier.wosid | 000187664700012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 904 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 893 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 115 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 283 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | XENOPUS OOCYTE MATURATION | - |
dc.subject.keywordPlus | ELEMENT-BINDING PROTEIN | - |
dc.subject.keywordPlus | CAMKII MESSENGER-RNA | - |
dc.subject.keywordPlus | DROSOPHILA ORB GENE | - |
dc.subject.keywordPlus | CYTOPLASMIC POLYADENYLATION | - |
dc.subject.keywordPlus | TRANSLATIONAL CONTROL | - |
dc.subject.keywordPlus | S6 KINASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | POTENTIATION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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