DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guan, ZH | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Lomvardas, S | - |
dc.contributor.author | Holick, K | - |
dc.contributor.author | Xu, SQ | - |
dc.contributor.author | K | - |
dc.contributor.author | el, ER | - |
dc.contributor.author | Schwartz, JH | - |
dc.date.accessioned | 2016-04-01T08:37:12Z | - |
dc.date.available | 2016-04-01T08:37:12Z | - |
dc.date.created | 2009-08-24 | - |
dc.date.issued | 2003-08-13 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.other | 2003-OAK-0000018245 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28385 | - |
dc.description.abstract | At Aplysia sensory-to-motor neuron synapses, the inhibitory neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFa) produces depression, and serotonin (5-HT) <LF>produces facilitation. Short-term depression has been found to result from the activation of a phospholipase A(2). The released arachidonate is metabolized by 12-lipoxygenase to active second messengers. We find that FMRFa leads to the phosphorylation and activation of p38 mitogen-activated protein (MAP) kinase. Short-term depression and the release of arachidonate are blocked by the specific p38 kinase inhibitor SB 203580. Both the inhibitor and an affinity-purified antibody raised against recombinant Aplysia p38 kinase injected into sensory neurons prevented long-term depression, which depends on the phosphorylation of translation factors cAMP response element-binding protein 2 (CREB2) and activating transcription factor 2. Facilitation produced by 5-HT, on the other hand, inactivates p38 kinase. Chromatin immunoprecipitation assays indicate that p38 kinase activates CREB2. p38 kinase also is pivotal in the bidirectional regulation of synaptic plasticity: when the kinase is inhibited, brief treatment with 5-HT that normally produces only short-term facilitation now results in long-term facilitation. Conversely, in sensory neurons injected with the activated kinase, long-term facilitation is blocked, and brief exposure to FMRFa, which normally results in short-term depression, results in long-term depression. We conclude that p38 kinase, which itself is bidirectionally regulated by FMRFa and 5-HT, acts as a modulator of synaptic plasticity by positively regulating depression and serving as an inhibitory constraint for facilitation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.relation.isPartOf | JOURNAL OF NEUROSCIENCE | - |
dc.subject | Aplysia | - |
dc.subject | histone deacetylase | - |
dc.subject | long-term depression | - |
dc.subject | long-term facilitation | - |
dc.subject | phospholipase A(2) | - |
dc.subject | p38 MAP kinase | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | CYTOSOLIC PHOSPHOLIPASE A(2) | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | ARACHIDONIC-ACID | - |
dc.subject | MOLECULAR-BIOLOGY | - |
dc.subject | CAM KINASE | - |
dc.subject | FACILITATION | - |
dc.subject | PLASTICITY | - |
dc.subject | STRESS | - |
dc.subject | MEMORY | - |
dc.title | P38 MAP KINASE MEDIATES BOTH SHORT-TERM AND LONG-TERM SYNAPTIC DEPRESSION IN APLYSIA | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Guan, ZH | - |
dc.author.google | Kim, JH | - |
dc.author.google | Lomvardas, S | - |
dc.author.google | Holick, K | - |
dc.author.google | Xu, SQ | - |
dc.author.google | Kandel, ER | - |
dc.author.google | Schwartz, JH | - |
dc.relation.volume | 23 | - |
dc.relation.issue | 19 | - |
dc.relation.startpage | 7317 | - |
dc.relation.lastpage | 7325 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | JOURNAL OF NEUROSCIENCE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE, v.23, no.19, pp.7317 - 7325 | - |
dc.identifier.wosid | 000184817700010 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 7325 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 7317 | - |
dc.citation.title | JOURNAL OF NEUROSCIENCE | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 61 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | CYTOSOLIC PHOSPHOLIPASE A(2) | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | ARACHIDONIC-ACID | - |
dc.subject.keywordPlus | MOLECULAR-BIOLOGY | - |
dc.subject.keywordPlus | CAM KINASE | - |
dc.subject.keywordPlus | FACILITATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordAuthor | Aplysia | - |
dc.subject.keywordAuthor | histone deacetylase | - |
dc.subject.keywordAuthor | long-term depression | - |
dc.subject.keywordAuthor | long-term facilitation | - |
dc.subject.keywordAuthor | phospholipase A(2) | - |
dc.subject.keywordAuthor | p38 MAP kinase | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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