DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Yang, JA | - |
dc.contributor.author | Jo, MH | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-04-01T08:39:03Z | - |
dc.date.available | 2016-04-01T08:39:03Z | - |
dc.date.created | 2009-08-24 | - |
dc.date.issued | 2009-06-10 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.other | 2009-OAK-0000018028 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28456 | - |
dc.description.abstract | An aptamer-functionalized silicon-nanowire (Si-NW) field effect transistor (FET) biosensor was successfully fabricated, characterized and applied to real-time electrical detection of binding with the target protein for biomedical applications. Surface modifications were carried out using 3-aminopropyl diethoxysilane and succinic anhydride to introduce amine and carboxyl groups onto Si substrates. Anti-thrombin aptamers with 5'-end amine groups were chemically grafted onto the surface-modified Si substrates through amide bond formation. Atomic force microscopic (AFM) analyses confirmed the successful immobilization of anti-thrombin aptamers on Si-NWs and their binding with thrombin samples. The anti-thrombin aptamers bound to Si-NWs through the linker appeared to have a mean height of approx. 4 nm and the thrombin/aptamer complex to have a mean height of approx. 8 nm. Fluorescence micrographs visualized the FITC-labeled thrombin after binding to anti-thrombin aptamers immobilized on Si-NWs. Furthermore, the anti-thrombin Si-NW FET biosensor was successfully applied to the real-time detection of electronic signals during and after binding with a thrombin sample at a concentration of approx. 330 pmol l(-1) and the thrombin in blood samples. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.title | The fabrication, characterization and application of aptamer- functionalized Si-nanowire FET biosensors | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1088/0957-4484/20/23/235501 | - |
dc.author.google | Kim, KS | - |
dc.author.google | Lee, HS | - |
dc.author.google | Yang, JA | - |
dc.author.google | Jo, MH | - |
dc.author.google | Hahn, SK | - |
dc.relation.volume | 20 | - |
dc.relation.issue | 23 | - |
dc.contributor.id | 10176415 | - |
dc.relation.journal | NANOTECHNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, v.20, no.23, pp.1 - 6 | - |
dc.identifier.wosid | 000266219800014 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 6 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NANOTECHNOLOGY | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Jo, MH | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-67649196721 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 66 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FIELD-EFFECT TRANSISTORS | - |
dc.subject.keywordPlus | LABEL-FREE | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | SELECTION | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | ARRAYS | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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