DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chamberlain, AK | - |
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Bowie, JU | - |
dc.date.accessioned | 2016-04-01T08:49:16Z | - |
dc.date.available | 2016-04-01T08:49:16Z | - |
dc.date.created | 2009-09-30 | - |
dc.date.issued | 2004-05-28 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.other | 2004-OAK-0000016786 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28840 | - |
dc.description.abstract | By analyzing transmembrane (TM) helices in known structures, we find that some polar amino acids are more frequent at the N terminus than at the C terminus. We propose the asymmetry occurs because most polar amino acids are better able to snorkel their polar atoms away from the membrane core at the N terminus than at the C terminus. Two findings lead us to this proposition: (1) side-chain conformations are influenced strongly by the N or C-terminal position of the amino acid in the bilayer, and (2) the favored snorkeling direction of an amino acid correlates well with its N to C-terminal composition bias. Our results suggest that TM helix predictions should incorporate an N to C-terminal composition bias, that rotamer preferences of TM side-chains are position-dependent, and that the ability to snorkel influences the evolutionary selection of amino acids for the helix N and C termini. (C) 2004 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD ELSEVIER SCIENCE L | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.subject | membrane | - |
dc.subject | protein | - |
dc.subject | side-chain | - |
dc.subject | polarity | - |
dc.subject | rotamer | - |
dc.subject | MEMBRANE-PROTEIN TOPOLOGY | - |
dc.subject | STATISTICAL-ANALYSIS | - |
dc.subject | CHARGED RESIDUES | - |
dc.subject | BACTERIORHODOPSIN LATTICE | - |
dc.subject | SECONDARY STRUCTURE | - |
dc.subject | AMPHIPATHIC HELIX | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | SIDE-CHAINS | - |
dc.subject | ASSOCIATION | - |
dc.title | SNORKELING PREFERENCES FOSTER AN AMINO ACID COMPOSITION BIAS IN TRANSMEMBRANE HELICES | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.JMB.2004.0 | - |
dc.author.google | Chamberlain, AK | - |
dc.author.google | Lee, Y | - |
dc.author.google | Kim, S | - |
dc.author.google | Bowie, JU | - |
dc.relation.volume | 339 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 471 | - |
dc.relation.lastpage | 479 | - |
dc.contributor.id | 10136479 | - |
dc.relation.journal | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.339, no.2, pp.471 - 479 | - |
dc.identifier.wosid | 000221561800019 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 479 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 471 | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 339 | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 57 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MEMBRANE-PROTEIN TOPOLOGY | - |
dc.subject.keywordPlus | STATISTICAL-ANALYSIS | - |
dc.subject.keywordPlus | CHARGED RESIDUES | - |
dc.subject.keywordPlus | BACTERIORHODOPSIN LATTICE | - |
dc.subject.keywordPlus | SECONDARY STRUCTURE | - |
dc.subject.keywordPlus | AMPHIPATHIC HELIX | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | SIDE-CHAINS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | membrane | - |
dc.subject.keywordAuthor | protein | - |
dc.subject.keywordAuthor | side-chain | - |
dc.subject.keywordAuthor | polarity | - |
dc.subject.keywordAuthor | rotamer | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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