DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hahn, SK | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Shimobouji, T | - |
dc.date.accessioned | 2016-04-01T09:05:38Z | - |
dc.date.available | 2016-04-01T09:05:38Z | - |
dc.date.created | 2009-08-24 | - |
dc.date.issued | 2007-03-15 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.other | 2007-OAK-0000010872 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29440 | - |
dc.description.abstract | An injectable hyaluronic acid (HA) microhydrogel was successfully developed as a novel drug carrier for controlled release formulation of protein drugs. HA hydrogels were prepared by the disulfide bond formation of thiolated HA (HA-SH). EPO was loaded in situ during HA-SH hydrogel preparation using an accelerating agent of sodium tetrathionate. The gelation time was drastically reduced from a day to 30 min when sodium tetrathionate was added for HA-SH hydrogel preparation. In vitro release of EPO in PBS at 37 degrees C showed that EPO was rapidly released for 3 days with an initial burst and then slowly up to 9 days from HA-SH hydrogels. HA-SH microhydrogels were prepared by the reactive spray drying of diluted HA-SH precursor solution. The mean particle size was similar to 2.3 mu m and the water content after spray drying was similar to 14%. Ellman's test showed that sodium tetrathionate contributed not only for rapid crosslinking reaction but also for the reduction of residual free thiol content in HA-SH microhydrogels after spray drying. EPO recovery from HA-SH microhydrogels after degradation with hyaluronidase SD was higher than 95%. The released EPO appeared to be intact from the analysis with RP-HPLC. According to in vivo release test of EPO from HA-SH microhydrogels in Sprague Dawley (SD) rats, elevated plasma concentration of EPO higher than 0.1 ng/mL, which is a critical minimal concentration for EPO efficacy, was maintained up to 7 days. There was no adverse effect during and after the in vivo tests. (c) 2006 Wiley Periodicals, Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.subject | controlled release | - |
dc.subject | erythropoietin | - |
dc.subject | hyaluronic acid | - |
dc.subject | sodium tetrathionate | - |
dc.subject | disulfide bond | - |
dc.subject | crosslinking | - |
dc.subject | spray drying | - |
dc.subject | microhydrogel | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | FUNCTIONALIZED DERIVATIVES | - |
dc.subject | SODIUM HYALURONATE | - |
dc.subject | HYDROGELS | - |
dc.title | Injectable hyaluronic acid microhydrogels for controlled release formulation of erythropoietin | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1002/JBM.A.30997 | - |
dc.author.google | Hahn, SK | - |
dc.author.google | Kim, JS | - |
dc.author.google | Shimobouji, T | - |
dc.relation.volume | 80A | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 916 | - |
dc.relation.lastpage | 924 | - |
dc.contributor.id | 10149037 | - |
dc.relation.journal | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.80A, no.4, pp.916 - 924 | - |
dc.identifier.wosid | 000244429600015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 924 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 916 | - |
dc.citation.title | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.citation.volume | 80A | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-33847224482 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 27 | - |
dc.description.scptc | 27 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FUNCTIONALIZED DERIVATIVES | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | controlled release | - |
dc.subject.keywordAuthor | erythropoietin | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | sodium tetrathionate | - |
dc.subject.keywordAuthor | disulfide bond | - |
dc.subject.keywordAuthor | crosslinking | - |
dc.subject.keywordAuthor | spray drying | - |
dc.subject.keywordAuthor | microhydrogel | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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