DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jee, M.H | - |
dc.contributor.author | Hong, K.Y | - |
dc.contributor.author | Park, J.H | - |
dc.contributor.author | Lee, J.S | - |
dc.contributor.author | Kim, H.S | - |
dc.contributor.author | Lee, S.H | - |
dc.contributor.author | Jang, S.K. | - |
dc.date.accessioned | 2016-04-08T07:33:11Z | - |
dc.date.available | 2016-04-08T07:33:11Z | - |
dc.date.created | 2016-02-29 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.other | 2015-OAK-0000035469 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29894 | - |
dc.description.abstract | Hepatitis C virus (HCV) is one of the leading causes of chronic liver inflammatory disease (hepatitis), which often leads to more severe diseases, such as liver fibrosis, cirrhosis, and hepatocellular carcinoma. Liver fibrosis, in particular, is a major pathogenic consequence of HCV infection, and transforming growth factor beta 1 (TGF-beta 1) plays a key role in its pathogenesis. Several HCV proteins have been suggested to either augment or suppress the expression of TGF-beta 1 by HCV-infected cells. Here, we report that TGF-beta 1 levels are elevated in HCV-infected hepatocytes cultured in vitro and in liver tissue of HCV patients. Notably, the level of TGF-beta 1 in media from in vitro-cultured HCV-infected hepatocytes was high enough to activate primary hepatic stellate cells isolated from rats. This indicates that TGF-beta 1 secreted by HCV-infected hepatocytes is likely to play a key role in the liver fibrosis observed in HCV patients. Moreover, we showed that HCV E2 protein triggers the production of TGF-beta 1 by HCV-infected cells through overproduction of glucose-regulated protein 94 (GRP94). | - |
dc.description.statementofresponsibility | open | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | Journal of Virology | - |
dc.title | New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor β1 Production through Glucose-Regulated Protein 94 | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1128/JVI.02976-15 | - |
dc.author.google | Min Hyeok Jee, Ka Young Hong, Ji Hoon Park, Jae Seung Lee, Hee Sun Kim, Song Hee Lee, Sung Key Jang | - |
dc.relation.volume | 90 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 3044 | - |
dc.relation.lastpage | 3055 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | Journal of Virology | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Virology, v.90, no.6, pp.3044 - 3055 | - |
dc.identifier.wosid | 000374110600029 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3055 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 3044 | - |
dc.citation.title | Journal of Virology | - |
dc.citation.volume | 90 | - |
dc.contributor.affiliatedAuthor | Jang, S.K. | - |
dc.identifier.scopusid | 2-s2.0-84961184431 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 7 | - |
dc.description.scptc | 7 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IN-VITRO PROLIFERATION | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | LIVER FIBROSIS | - |
dc.subject.keywordPlus | STELLATE CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
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