Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis
SCIE
SCOPUS
- Title
- Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis
- Authors
- Hyungkook Jeon; Youngkyu Kim; Lim, G
- Date Issued
- 2016-01-28
- Publisher
- Nature Publishing Group
- Abstract
- In this paper, we introduce pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced mu-FFE), a novel continuous separation method. In our separation system, the external flow and electric field are applied to particles, such that particle movement is affected by pressure-driven flow, electroosmosis, and electrophoresis. We then analyzed the hydrodynamic drag force and electrophoretic force applied to the particles in opposite directions. Based on this analysis, micro-and nano-sized particles were separated according to their electrophoretic mobilities with high separation efficiency. Because the separation can be achieved in a simple T-shaped microchannel, without the use of internal electrodes, it offers the advantages of low-cost, simple device fabrication and bubble-free operation, compared with conventional mu-FFE methods. Therefore, we expect the proposed separation method to have a wide range of filtering/separation applications in biochemical analysis.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29918
- DOI
- 10.1038/SREP19911
- ISSN
- 2045-2322
- Article Type
- Article
- Citation
- Scientific Reports, vol. 6, 2016-01-28
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