DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sugawara, R | - |
dc.contributor.author | Lee, EJ | - |
dc.contributor.author | Jang, MS | - |
dc.contributor.author | Jeun, EJ | - |
dc.contributor.author | Hong, CP | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Park, A | - |
dc.contributor.author | Yun, CH | - |
dc.contributor.author | Hong, SW | - |
dc.contributor.author | KIM, YOU ME | - |
dc.contributor.author | Seoh, JY | - |
dc.contributor.author | Jung, Y | - |
dc.contributor.author | Surh, CD | - |
dc.contributor.author | Miyasaka, M | - |
dc.contributor.author | Yang, BG | - |
dc.contributor.author | Jang, MH | - |
dc.date.accessioned | 2016-08-26T07:34:20Z | - |
dc.date.available | 2016-08-26T07:34:20Z | - |
dc.date.created | 2016-06-07 | - |
dc.date.issued | 2016-04-04 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.other | 2016-OAK-0000035777 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29968 | - |
dc.description.abstract | Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. | - |
dc.description.statementofresponsibility | open | - |
dc.language | English | - |
dc.publisher | Journal of Experimental Medicine | - |
dc.relation.isPartOf | Journal of Experimental Medicine | - |
dc.title | Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1084/JEM.20141388 | - |
dc.author.google | Sugawara, R | - |
dc.author.google | Lee, EJ | - |
dc.author.google | Jang, MS | - |
dc.author.google | Jeun, EJ | - |
dc.author.google | Hong, CP | - |
dc.author.google | Kim, JH | - |
dc.author.google | Park, A | - |
dc.author.google | Yun, CH | - |
dc.author.google | Hong, SW | - |
dc.author.google | Kim, YM | - |
dc.author.google | Seoh, JY | - |
dc.author.google | Jung, Y | - |
dc.author.google | Surh, CD | - |
dc.author.google | Miyasaka, M | - |
dc.author.google | Yang, BG | - |
dc.author.google | Jang, MH | - |
dc.relation.volume | 213 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 555 | - |
dc.relation.lastpage | 567 | - |
dc.contributor.id | 10201353 | - |
dc.relation.journal | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Experimental Medicine, v.213, no.4, pp.555 - 567 | - |
dc.identifier.wosid | 000373394100008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 567 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 555 | - |
dc.citation.title | Journal of Experimental Medicine | - |
dc.citation.volume | 213 | - |
dc.contributor.affiliatedAuthor | KIM, YOU ME | - |
dc.contributor.affiliatedAuthor | Surh, CD | - |
dc.identifier.scopusid | 2-s2.0-84995455338 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | IL-1-BETA | - |
dc.subject.keywordPlus | INTERLEUKIN-23 | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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