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Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats SCIE SCOPUS

Title
Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats
Authors
Yeom, EByeon, HLee, SJ
Date Issued
2016-02-22
Publisher
NATURE PUBLISHING GROUP
Abstract
Diabetes mellitus with abnormal glucose concentration is associated with changes in hemorheological properties, endothelial function, and platelets hyperactivity. Disturbances may significantly be responsible for diabetes-related vascular complications. In this study, hemorheological and hemodynamic properties were measured according to diabetic duration after streptozotocin treatment in rats. For ex vivo measurements, an extracorporeal model was adopted. Flow rate and blood viscosity were measured using a microfluidic device. Erythrocyte aggregation and morphological parameters of erythrocytes were measured by modified erythrocyte sedimentation rate and the phase-contrast holography under in vitro conditions. The platelet aggregation and mean pressure in the femoral artery were estimated under ex vivo conditions. Hemorheological properties including blood viscosity, erythrocyte aggregation and shape parameters for the control group are significantly different with those for diabetic groups. The changes with respect to diabetic duration were relatively unnoticeable. However, the platelet aggregation is strongly dependent on the diabetic duration. Based on these results, hyperglycemia exposure may induce hemorheological variations in early stages of diabetes mellitus. High platelet aggregation may become more pronounced according to the diabetic duration caused by variations in hemorheological properties resulting in endothelial dysfunction. This study would be helpful in understanding the effects of diabetic duration on biophysical properties.
Keywords
BLOOD-CELL MEMBRANE; ERYTHROCYTE AGGREGATION; THROMBUS FORMATION; ENDOTHELIAL FUNCTION; MELLITUS; VISCOSITY; ULTRASOUND; HEMATOCRIT; MICROSCOPY; ATHEROSCLEROSIS
URI
https://oasis.postech.ac.kr/handle/2014.oak/29978
DOI
10.1038/SREP21913
ISSN
2045-2322
Article Type
Article
Citation
SCIENTIFIC REPORTS, vol. 6, page. 21913, 2016-02-22
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이상준LEE, SANG JOON
Dept of Mechanical Enginrg
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