DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JB | - |
dc.contributor.author | Lee, CS | - |
dc.contributor.author | Jang, JH | - |
dc.contributor.author | Ghim, J | - |
dc.contributor.author | Kim, YJ | - |
dc.contributor.author | You, S | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2017-07-19T08:01:55Z | - |
dc.date.available | 2017-07-19T08:01:55Z | - |
dc.date.created | 2013-01-31 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1474-175X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/34211 | - |
dc.description.abstract | Phospholipases (PLC, PLD and PLA) are essential mediators of intracellular and intercellular signalling. They can function as phospholipid-hydrolysing enzymes that can generate many bioactive lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid and arachidonic acid. Lipid mediators generated by phospholipases regulate multiple cellular processes that can promote tumorigenesis, including proliferation, migration, invasion and angiogenesis. Although many individual phospholipases have been extensively studied, how phospholipases regulate diverse cancer-associated cellular processes and the interplay between different phospholipases have yet to be fully elucidated. A thorough understanding of the cancer-associated signalling networks of phospholipases is necessary to determine whether these enzymes can be targeted therapeutically. | - |
dc.language | English | - |
dc.publisher | NATURE REVIEWS CANCER | - |
dc.relation.isPartOf | NATURE REVIEWS CANCER | - |
dc.subject | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | IIA SECRETORY PHOSPHOLIPASE-A2 | - |
dc.subject | PLECKSTRIN HOMOLOGY DOMAIN | - |
dc.subject | SKIN TUMOR-DEVELOPMENT | - |
dc.subject | BREAST-CANCER | - |
dc.subject | LYSOPHOSPHATIDIC ACID | - |
dc.subject | PHOSPHATIDIC-ACID | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | COLON TUMORIGENESIS | - |
dc.title | Phospholipase signalling networks in cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/NRC3379 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE REVIEWS CANCER, v.12, no.11, pp.782 - 792 | - |
dc.identifier.wosid | 000310433900015 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 792 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 782 | - |
dc.citation.title | NATURE REVIEWS CANCER | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.identifier.scopusid | 2-s2.0-84867875513 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 76 | - |
dc.description.scptc | 70 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Review | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | IIA SECRETORY PHOSPHOLIPASE-A2 | - |
dc.subject.keywordPlus | PHOX HOMOLOGY DOMAIN | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | LYSOPHOSPHATIDIC ACID | - |
dc.subject.keywordPlus | PHOSPHATIDIC-ACID | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | DEPENDENT ACTIVATION | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCHANGE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
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