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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Beack, S | - |
| dc.contributor.author | Choi, JS | - |
| dc.contributor.author | Lee, JH | - |
| dc.contributor.author | Kim, H | - |
| dc.contributor.author | Kim, KH | - |
| dc.contributor.author | Joo, CK | - |
| dc.contributor.author | Hahn, SK | - |
| dc.date.accessioned | 2017-07-19T12:12:14Z | - |
| dc.date.available | 2017-07-19T12:12:14Z | - |
| dc.date.created | 2016-01-11 | - |
| dc.date.issued | 2015-01 | - |
| dc.identifier.issn | 1743-5889 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35431 | - |
| dc.description.abstract | Aim: Two-photon microscopy was performed to visualize ocular distribution of Flt1 peptide-hyaluronate (HA) conjugate micelles for eye drop treatment of corneal neovascularization. Materials & methods: Flt1 peptide-HA conjugate micelles were topically administered to the eye for two-photon microscopy and antiangiogenic effect assessment after silver nitrate cauterization. Results: In vivo two-photon microscopy revealed that Flt1 peptide-HA conjugate micelles were absorbed and remained on the corneal epithelia with an increased residence time, facilitating the corneal delivery of carboxyfluorescein succinimidyl ester (CFSE) as a model drug. Furthermore, repeated eye drops of Flt1 peptide-HA conjugate micelles showed comparable therapeutic effect to the subconjunctival injection on the corneal neovascularization. Discussion & conclusion: We confirmed the feasibility of Flt1 peptide-HA conjugate micelles for eye drop treatment of corneal neovascularization. | - |
| dc.language | English | - |
| dc.publisher | FUTURE MEDICINE LTD | - |
| dc.relation.isPartOf | NANOMEDICINE | - |
| dc.title | Two-photon microscopy of a Flt1 peptide-hyaluronate conjugate | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.2217/NNM.15.71 | - |
| dc.type.rims | ART | - |
| dc.identifier.bibliographicCitation | NANOMEDICINE, v.10, no.15, pp.2315 - 2324 | - |
| dc.identifier.wosid | 000360222600003 | - |
| dc.date.tcdate | 2019-03-01 | - |
| dc.citation.endPage | 2324 | - |
| dc.citation.number | 15 | - |
| dc.citation.startPage | 2315 | - |
| dc.citation.title | NANOMEDICINE | - |
| dc.citation.volume | 10 | - |
| dc.contributor.affiliatedAuthor | Kim, KH | - |
| dc.contributor.affiliatedAuthor | Hahn, SK | - |
| dc.identifier.scopusid | 2-s2.0-84940555730 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
| dc.description.wostc | 3 | - |
| dc.description.scptc | 3 | * |
| dc.date.scptcdate | 2018-05-121 | * |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | CORNEAL NEOVASCULARIZATION | - |
| dc.subject.keywordPlus | CONFOCAL MICROSCOPY | - |
| dc.subject.keywordPlus | ANTI-FLT1 PEPTIDE | - |
| dc.subject.keywordPlus | DRUG-DELIVERY | - |
| dc.subject.keywordPlus | IN-VITRO | - |
| dc.subject.keywordPlus | RESOLUTION | - |
| dc.subject.keywordPlus | FLUORESCENCE | - |
| dc.subject.keywordPlus | RANIBIZUMAB | - |
| dc.subject.keywordPlus | RECEPTOR | - |
| dc.subject.keywordAuthor | corneal neovascularization | - |
| dc.subject.keywordAuthor | eye drop | - |
| dc.subject.keywordAuthor | Flt1 peptide | - |
| dc.subject.keywordAuthor | hyaluronate | - |
| dc.subject.keywordAuthor | two-photon microscopy | - |
| dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
| dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
| dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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