Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4
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- Title
- Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4
- Authors
- Saucet, SB; Ma, Y; Sarris, PF; Furzer, OJ; Sohn, KH; Jones, JDG
- Date Issued
- 2015-03
- Publisher
- Nature Publishing Group
- Abstract
- Plant immunity requires recognition of pathogen effectors by intracellular NB-LRR immune receptors encoded by Resistance (R) genes. Most R proteins recognize a specific effector, but some function in pairs that recognize multiple effectors. Arabidopsis thaliana TIR-NB-LRR proteins RRS1-R and RPS4 together recognize two bacterial effectors, AvrRps4 from Pseudomonas syringae and PopP2 from Ralstonia solanacearum. However, AvrRps4, but not PopP2, is recognized in rrs1/rps4 mutants. We reveal an R gene pair that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, which confers recognition of AvrRps4 but not PopP2. Like RRS1/RPS4, RRS1B/RPS4B proteins associate and activate defence genes upon AvrRps4 recognition. Inappropriate combinations (RRS1/RPS4B or RRS1B/RPS4) are non-functional and this specificity is not TIR domain dependent. Distinct putative orthologues of both pairs are maintained in the genomes of Arabidopsis thaliana relatives and are likely derived from a common ancestor pair. Our results provide novel insights into paired R gene function and evolution.
- Keywords
- NB-LRR PROTEIN; MULTIPLE SEQUENCE ALIGNMENT; TOBACCO-MOSAIC-VIRUS; DISEASE-RESISTANCE; CELL-DEATH; IMMUNE RECEPTORS; TRANSCRIPTION FACTORS; PATHOGEN EFFECTORS; DEFENSE RESPONSES; NATURAL VARIATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/35764
- DOI
- 10.1038/NCOMMS7338
- ISSN
- 2041-1723
- Article Type
- Article
- Citation
- NATURE COMMUNICATIONS, vol. 6, 2015-03
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