Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation
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- Title
- Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation
- Authors
- Jeong, GY; Ricco, R; Liang, K; Ludwig, J; Kim, JO; Falcaro, P; Kim, DP
- Date Issued
- 2015-12-08
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Functional bio-MOF hollow spheres with controlled size in the 35-2000 mu m range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanopartides (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/35814
- DOI
- 10.1021/ACS.CHEMMATER.5B02847
- ISSN
- 0897-4756
- Article Type
- Article
- Citation
- CHEMISTRY OF MATERIALS, vol. 27, no. 23, page. 7903 - 7909, 2015-12-08
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