DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, KJ | - |
dc.contributor.author | Lee, HR | - |
dc.contributor.author | Jo, YS | - |
dc.contributor.author | An, K | - |
dc.contributor.author | Jung, SY | - |
dc.contributor.author | Jeong, MW | - |
dc.contributor.author | Kwon, SK | - |
dc.contributor.author | Kim, NS | - |
dc.contributor.author | Jeong, HW | - |
dc.contributor.author | Ahn, SH | - |
dc.contributor.author | Kim, KT | - |
dc.contributor.author | Lee, K | - |
dc.contributor.author | Kim, E | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Choi, JS | - |
dc.contributor.author | Kaang, BK | - |
dc.contributor.author | Kong, YY | - |
dc.date.accessioned | 2017-07-19T12:30:25Z | - |
dc.date.available | 2017-07-19T12:30:25Z | - |
dc.date.created | 2013-01-14 | - |
dc.date.issued | 2012-10-30 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35926 | - |
dc.description.abstract | Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus. | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | Molecular Brain | - |
dc.title | Mind bomb-1 is an essential modulator of long-termmemory and synaptic plasticity via the Notchsignaling pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/1756-6606-5-40 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Molecular Brain, v.5, pp.40 | - |
dc.identifier.wosid | 000315052400001 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.startPage | 40 | - |
dc.citation.title | Molecular Brain | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-84867900905 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | MOLECULAR-BIOLOGY | - |
dc.subject.keywordPlus | CELL FATE | - |
dc.subject.keywordPlus | PKM-ZETA | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | Mind bomb-1 | - |
dc.subject.keywordAuthor | Notch | - |
dc.subject.keywordAuthor | Synaptic plasticity | - |
dc.subject.keywordAuthor | Memory | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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