DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, S | - |
dc.contributor.author | Bhang, SH | - |
dc.contributor.author | Hwang, S | - |
dc.contributor.author | Yoon, JK | - |
dc.contributor.author | Song, J | - |
dc.contributor.author | Jang, HK | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Kim, BS | - |
dc.date.accessioned | 2017-07-19T12:42:45Z | - |
dc.date.available | 2017-07-19T12:42:45Z | - |
dc.date.created | 2016-01-26 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36301 | - |
dc.description.abstract | Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 degrees C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS NANO | - |
dc.title | Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ACSNANO.5B02207 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS NANO, v.9, no.10, pp.9678 - 9690 | - |
dc.identifier.wosid | 000363915300024 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 9690 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 9678 | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.identifier.scopusid | 2-s2.0-84946038364 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 52 | - |
dc.description.scptc | 37 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | NANOSHELLS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | pH-sensitive | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | tumor tropism | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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