Discovery of Prostate Specific Antigen Pattern to Predict Castration Resistant Prostate Cancer of Androgen Deprivation Therapy
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SCOPUS
- Title
- Discovery of Prostate Specific Antigen Pattern to Predict Castration Resistant Prostate Cancer of Androgen Deprivation Therapy
- Authors
- Kim, Y; Park, Y.H; Lee, J.Y; Choi, I.Y; Yu, H.
- Date Issued
- 2016-07-18
- Publisher
- BioMed Central
- Abstract
- Background: Prostate specific antigen (PSA) is an important biomarker to monitor the response to the treatment, but has not been fully utilized as a whole sequence. We used a longitudinal biomarker PSA to discover a new prognostic pattern that predicts castration-resistant prostate cancer (CRPC) after androgen deprivation therapy. Methods: We transformed the longitudinal PSA into a discrete sequence, used frequent sequential pattern mining to find candidate patterns from the sequences, and selected the most predictive and informative pattern among the candidates. Results: Patients were less likely to be CRPC if, after PSA values reach nadir, the PSA decreases more than 0.048 ng/ml during a month, and the decrease occurs again. This pattern significantly increased the accuracy of predicting CRPC by supplementing information provided by existing PSA patterns such as pretreatment PSA. Conclusions: This result can help clinicians to stratify men by the risk of CRPC and to determine the patient that needs intensive follow-up.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36415
- DOI
- 10.1186/S12911-016-0297-0
- ISSN
- 1472-6947
- Article Type
- Article
- Citation
- BMC Medical Informatics and Decision Making, vol. 16, no. SUPPL 1, page. 63, 2016-07-18
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