DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, HW | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Song, HB | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kim, K | - |
dc.contributor.author | Kim, WJ | - |
dc.date.accessioned | 2017-07-19T12:57:58Z | - |
dc.date.available | 2017-07-19T12:57:58Z | - |
dc.date.created | 2016-12-30 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36702 | - |
dc.description.abstract | We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaPcoating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS Nano | - |
dc.title | Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsnano.5b07483 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS Nano, v.10, no.4, pp.4199 - 4208 | - |
dc.identifier.wosid | 000375245000036 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 4208 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 4199 | - |
dc.citation.title | ACS Nano | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Kim, K | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-84968735648 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 28 | - |
dc.description.scptc | 18 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | CALCIUM-PHOSPHATE NANOPARTICLES | - |
dc.subject.keywordPlus | CONTROLLED DRUG-DELIVERY | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | DONORS | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | nitric oxide delivery | - |
dc.subject.keywordAuthor | calcium phosphate | - |
dc.subject.keywordAuthor | pH-jump reagent | - |
dc.subject.keywordAuthor | gatekeeper | - |
dc.subject.keywordAuthor | corneal wound healing | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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