DC Field | Value | Language |
---|---|---|
dc.contributor.author | Avnish Kumar Mishr | - |
dc.contributor.author | Jicheol Park | - |
dc.contributor.author | Vincent Joseph K.L | - |
dc.contributor.author | Sandip Maiti | - |
dc.contributor.author | Jongheon Kwak | - |
dc.contributor.author | Chungryong choi | - |
dc.contributor.author | Seung Hyun | - |
dc.contributor.author | Kim, JK | - |
dc.date.accessioned | 2017-07-19T13:27:16Z | - |
dc.date.available | 2017-07-19T13:27:16Z | - |
dc.date.created | 2017-02-02 | - |
dc.date.issued | 2016-09-25 | - |
dc.identifier.issn | 0032-3861 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37002 | - |
dc.description.abstract | Well-defined amphiphilic and biocompatible poly(vinyl alcohol)block-poly(L-lactide) copolymers (PVA-b-PLLA) were synthesized by the combination of reversible addition-fragmentation chain transfer (RAFT), ring opening polymerization (ROP), and click chemistry. First, an innovative azide-functionalized xanthate mediated chain transfer agent (CTA) [S-(3-azidopropyl propanamide)-(O-butyl xanthate)] was synthesized and used for vinyl acetate (VAc) polymerization through RAFT. Then, azide-terminated poly(vinyl acetate) (azide-PVAc) was converted to the corresponding azide-terminated poly(vinyl alcohol) (azide-PVA) through hydrolysis. Alkyne-terminated poly (L-lactide) (alkyne-PLLA) was synthesized via ROP using a bifunctional initiator, having an alkyne and a hydroxyl group. Finally, azide-PVA and alkyne-PLLA were coupled by 1,3 cycloaddition click reaction to get PVA-b-PLLA. Synthesized azide-PVAc, azide-PVA, alkyne-PLLA and PVA-b-PLLA were characterized by size exclusion chromatography and H-1 NMR spectroscopy. The self-assembly of PVA-b-PLLA in water was investigated by transmission electron microscope, atomic force microscopy, dynamic light scattering and H-1 NMR spectroscopy. Spherical micelles in water were clearly observed. The critical micelle concentration of PVA-b-PLLA in water was determined by fluorescence spectroscopy, and it was decreased with increasing the molecular weight of PLLA block. PVA-b-PLLA exhibited low cytotoxicity which could be used in biomedical application. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | Polymer | - |
dc.title | Synthesis and self-assembly of amphiphilic and biocompatible poly(vinyl alcohol)-block-poly(l-lactide) copolymer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.POLYMER.2016.08.005 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Polymer, v.100, pp.28 - 36 | - |
dc.identifier.wosid | 000383925800004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 36 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | Polymer | - |
dc.citation.volume | 100 | - |
dc.contributor.affiliatedAuthor | Avnish Kumar Mishr | - |
dc.contributor.affiliatedAuthor | Sandip Maiti | - |
dc.contributor.affiliatedAuthor | Chungryong choi | - |
dc.contributor.affiliatedAuthor | Kim, JK | - |
dc.identifier.scopusid | 2-s2.0-84981516003 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 2 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LIVING CATIONIC-POLYMERIZATION | - |
dc.subject.keywordPlus | MEDIATED RAFT POLYMERIZATION | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | SILVER NANOPARTICLES | - |
dc.subject.keywordPlus | CLICK CHEMISTRY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | VINYL-ACETATE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | XANTHATE | - |
dc.subject.keywordPlus | ALCOHOL) | - |
dc.subject.keywordAuthor | Poly(vinyl alcohol)-block-poly(L-lactide) copolymers | - |
dc.subject.keywordAuthor | Azide-functionalized RAFT initiator | - |
dc.subject.keywordAuthor | Amphiphilic and biocompatible materials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
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