Bioinspired Dual Stimuli-Responsive Membranous System with Multiple On–Off Gates
SCIE
SCOPUS
- Title
- Bioinspired Dual Stimuli-Responsive Membranous System with Multiple On–Off Gates
- Authors
- Lee, BY; hyun Seung; Jeon, G; Eun Young Kim; Kim, J; Kim, WJ; Kim, JR
- Date Issued
- 2016-05-11
- Publisher
- ACS Publications
- Abstract
- Stimuli-responsive polymers have been widely used for controlled release of several biomolecules. In general, a single stimulus among various stimuli, for instance, temperature, pH, or light, has been used for these polymers. Although some stimuli are applied together, one cannot control each stimulus independently at a given stimulus-responsive polymer. However, to mimic biological system like cell membrane, multiple on off gates utilizing independent control of dual (or multiple) stimuli should be used. Here, we introduce a stimuli-responsive membrane controlled by two orthogonal stimuli. For this purpose, the top and the bottom parts of anodized aluminum oxide membrane walls are independently grafted by thermoresponsive poly(N-isopropylacrylamide) and pH-responsive poly(acrylic acid), respectively, by using surface-initiated atom transfer radical polymerization. The membrane clearly showed two independent on off gates depending on temperature and pH. Furthermore, through light irradiation of two different wavelengths (near-infrared and ultraviolet), temperature and pH were also controlled independently and promptly. Thus, this membrane shows two independent on-off gating of the transport of a model biomolecule of fluorescein isothiocyanate-labeled bovine serum albumin. This strategy suggests the potential of independently modified membrane in layers as stimuli-responsive on off gates for the application of artificial cell membrane.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37012
- DOI
- 10.1021/ACSAMI.6B01788
- ISSN
- 1944-8244
- Article Type
- Article
- Citation
- ACS Applied Mater.Inter, vol. 8, no. 18, page. 11758 - 11764, 2016-05-11
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.