DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, C | - |
dc.contributor.author | Kwon, W | - |
dc.contributor.author | Beack, S | - |
dc.contributor.author | Lee, D | - |
dc.contributor.author | Park, Y | - |
dc.contributor.author | Kim, H | - |
dc.contributor.author | Hahn, SK | - |
dc.contributor.author | Rhee, SW | - |
dc.contributor.author | Kim, C | - |
dc.date.accessioned | 2017-07-19T13:29:16Z | - |
dc.date.available | 2017-07-19T13:29:16Z | - |
dc.date.created | 2017-02-09 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 1838-7640 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37075 | - |
dc.description.abstract | Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability. Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test. | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | Theranostics | - |
dc.title | Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.7150/thno.16923 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Theranostics, v.6, no.12, pp.2196 - 2208 | - |
dc.identifier.wosid | 000388505900014 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2208 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2196 | - |
dc.citation.title | Theranostics | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.contributor.affiliatedAuthor | Kim, C | - |
dc.identifier.scopusid | 2-s2.0-84995480720 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 26 | - |
dc.description.scptc | 9 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SEMICONDUCTING POLYMER NANOPARTICLES | - |
dc.subject.keywordPlus | SURFACE-PLASMON RESONANCE | - |
dc.subject.keywordPlus | GOLD NANORODS | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL NANOPARTICLES | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | DOTS | - |
dc.subject.keywordPlus | THERANOSTICS | - |
dc.subject.keywordPlus | FLUORESCENT | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordAuthor | Carbon nanodot | - |
dc.subject.keywordAuthor | Nitrogen doping | - |
dc.subject.keywordAuthor | Photoacoustic | - |
dc.subject.keywordAuthor | Photothermal | - |
dc.subject.keywordAuthor | Biodegradation | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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