DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, K | - |
dc.contributor.author | Kim, H | - |
dc.contributor.author | An, K | - |
dc.contributor.author | Kwon, OB | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Cha, JH | - |
dc.contributor.author | Kim, MH | - |
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Cho, K | - |
dc.contributor.author | Kim, HS | - |
dc.date.accessioned | 2017-07-19T13:30:05Z | - |
dc.date.available | 2017-07-19T13:30:05Z | - |
dc.date.created | 2017-02-07 | - |
dc.date.issued | 2016-10-06 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37105 | - |
dc.description.abstract | MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer's disease (AD). We found that oligomeric A beta(1-42) treatment diminished miR-188-5p expression in primary hippocampal neuron cultures and that miR-188-5p rescued the A beta(1-42)-mediated synapse elimination and synaptic dysfunctions. Moreover, the impairments in cognitive function and synaptic transmission observed in 7-month-old five familial AD (5XFAD) transgenic mice, were ameliorated via viral-mediated expression of miR-188-5p. miR-188-5p expression was down-regulated in the brain tissues from AD patients and 5XFAD mice. The addition of miR-188-5p rescued the reduction in dendritic spine density in the primary hippocampal neurons treated with oligomeric A beta(1-42) and cultured from 5XFAD mice. The reduction in the frequency of mEPSCs was also restored by addition of miR-188-5p. The impairments in basal fEPSPs and cognition observed in 7-month-old 5XFAD mice were ameliorated via the viral-mediated expression of miR-188-5p in the hippocampus. Furthermore, we found that miR-188 expression is CREB-dependent. Taken together, our results suggest that dysregulation of miR-188-5p expression contributes to the pathogenesis of AD by inducing synaptic dysfunction and cognitive deficits associated with A beta-mediated pathophysiology in the disease. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.title | Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/SREP34433 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.6 | - |
dc.identifier.wosid | 000385172400001 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Lee, Y | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-84990858943 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.description.scptc | 6 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CULTURED HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CALCINEURIN ACTIVATION | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | NEUROPILIN-2 | - |
dc.subject.keywordPlus | BRAIN | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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