Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
SCIE
SCOPUS
- Title
- Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
- Authors
- Yang, Y.R; Song, S; Hwang, H; Jung, J.H; Kim, S.-J; Yoon, S; Hur, J.-H; Park, J.-I; Lee, C; Nam, D; Seo, Y.-K; Kim, J.-H; Rhim, H; Suh, P.-G.
- Date Issued
- 2017-04
- Publisher
- Nature Publishing Group
- Abstract
- O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/38149
- DOI
- 10.1038/SREP44921
- ISSN
- 2045-2322
- Article Type
- Article
- Citation
- Scientific Reports, vol. 7, page. 44921, 2017-04
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