DC Field | Value | Language |
---|---|---|
dc.contributor.author | Renkema, KR | - |
dc.contributor.author | Lee, JY | - |
dc.contributor.author | Lee, YJ | - |
dc.contributor.author | Hamilton, SE | - |
dc.contributor.author | Hogquist, KA | - |
dc.contributor.author | Jameson, SC | - |
dc.date.accessioned | 2018-01-04T11:27:57Z | - |
dc.date.available | 2018-01-04T11:27:57Z | - |
dc.date.created | 2017-07-16 | - |
dc.date.issued | 2016-06-27 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39263 | - |
dc.description.abstract | Previous studies have revealed that a population of innate memory CD8(+) T cells is generated in response to IL-4, first appearing in the thymus and bearing high expression levels of Eomesodermin (Eomes) but not T-bet. However, the antigen specificity and functional properties of these cells is poorly defined. In this study, we show that IL-4 regulates not only the frequency and function of innate memory CD8(+) T cells, but also regulates Eomes expression levels and functional reactivity of naive CD8(+) T cells. Lack of IL-4 responsiveness attenuates the capacity of CD8(+) T cells to mount a robust response to lymphocytic choriomeningitis virus infection, with both quantitative and qualitative effects on effector and memory antigen-specific CD8(+) T cells. Unexpectedly, we found that, although numerically rare, memory phenotype CD8(+) T cells in IL-4R alpha-deficient mice exhibited enhanced reactivity after in vitro and in vivo stimulation. Importantly, our data revealed that these effects of IL-4 exposure occur before, not during, infection. Together, these data show that IL-4 influences the entire peripheral CD8(+) T cell pool, influencing expression of T-box transcription factors, functional reactivity, and the capacity to respond to infection. These findings indicate that IL-4, a canonical Th2 cell cytokine, can sometimes promote rather than impair Th1 cell-type immune responses. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.title | IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1084/JEM.20151359 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.213, no.7, pp.1319 - 1329 | - |
dc.identifier.wosid | 000380849800017 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1329 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1319 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 213 | - |
dc.contributor.affiliatedAuthor | Lee, YJ | - |
dc.identifier.scopusid | 2-s2.0-84977656581 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 3 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MEMORY-PHENOTYPE | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | DEFINES | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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