DC Field | Value | Language |
---|---|---|
dc.contributor.author | Malhotra, D | - |
dc.contributor.author | Linehan, JL | - |
dc.contributor.author | Dileepan, T | - |
dc.contributor.author | Lee, YJ | - |
dc.contributor.author | Purtha, WE | - |
dc.contributor.author | Lu, JV | - |
dc.contributor.author | Nelson, RW | - |
dc.contributor.author | Fife, BT | - |
dc.contributor.author | Orr, HT | - |
dc.contributor.author | Anderson, MS | - |
dc.contributor.author | Hogquist, KA | - |
dc.contributor.author | Jenkins, MK | - |
dc.date.accessioned | 2018-01-04T11:53:43Z | - |
dc.date.available | 2018-01-04T11:53:43Z | - |
dc.date.created | 2017-07-16 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39289 | - |
dc.description.abstract | Studies of repertoires of mouse monoclonal CD4(+) T cells have revealed several mechanisms of self-tolerance; however, which mechanisms operate in normal repertoires is unclear. Here we studied polyclonal CD4(+) T cells specific for green fluorescent protein expressed in various organs, which allowed us to determine the effects of specific expression patterns on the same epitope-specific T cells. Peptide's presented uniformly by thymic antigen-presenting cells were tolerated by clonal deletion, whereas peptides excluded from the thymus were ignored. Peptides with limited thymic expression induced partial clonal deletion and impaired effector T cell potential but enhanced regulatory T cell potential. These mechanisms were also active for T cell populations specific for endogenously expressed self antigens. Thus, the immunotolerance of polyclonal CD4(+) T cells was maintained by distinct mechanisms, according to self-peptide expression patterns. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.title | Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/NI.3327 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.17, no.2, pp.187 - 195 | - |
dc.identifier.wosid | 000368571500012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 195 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 187 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Lee, YJ | - |
dc.identifier.scopusid | 2-s2.0-84955100080 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 49 | - |
dc.description.scptc | 37 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GREEN FLUORESCENT PROTEIN | - |
dc.subject.keywordPlus | PERIPHERAL TOLERANCE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | NEGATIVE SELECTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | REPERTOIRE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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