RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan
SCOPUS
- Title
- RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan
- Authors
- Sangsoon Park; Yoonji Jung; Seon Woo A. An; Heehwa G. Son; Wooseon Hwang; Dongyeop Lee; Murat Artan; Hae-Eun H. Park,; Dae-Eun Jeong; Seung-Jae V. Lee
- Date Issued
- 2017-12
- Publisher
- F1000Research 2017
- Abstract
- Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.
Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen.
Results: We found that feeding worms with bacteria expressing double-stranded RNA against each of 24 out of total 29 C. elegans α-arrestins had little effect on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity.
Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41048
- DOI
- 10.12688/f1000research.12337.2
- ISSN
- 2046-1402
- Article Type
- Article
- Citation
- F1000Research, vol. 6, no. 1515, 2017-12
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- There are no files associated with this item.
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