Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library
SCIE
SCOPUS
- Title
- Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library
- Authors
- Armstrong, JI; Portley, AR; Chang, Young-Tae; Nierengarten, DM; Cook, BN; Bowman, KG; Bishop, A; Gray, NS; Shokat, KM; Schultz, PG; Bertozzi, CR
- Date Issued
- 2000-04
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- Chemical tools for biological investigations of carbohydrate sulfotransferases—a class of enzymes that has been characterized only recently—have been developed by using a small-molecule library-screening approach. The inhibitor screen included 139 compounds comprising selected structures from purine libraries as well as commercially available protein-kinase inhibitors and representatives from other kinase-inhibitor families. Like kinases, carbohydrate sulfotransferases have attracted significant interest because of their roles in a variety of disease states including chronic inflammation and tumor metastasis.
- Keywords
- RHIZOBIUM-MELILOTI; ESTROGEN SULFOTRANSFERASE; CRYSTAL-STRUCTURE; PROTEIN; NODULATION; NODH; SULFATION; SIGNALS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50145
- DOI
- 10.1002/(SICI)1521-3773(20000403)39:7<1303::AID-ANIE1303>3.0.CO;2-0
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39, no. 7, page. 1303 - +, 2000-04
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- There are no files associated with this item.
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