DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Bork, Jacqueline T. | - |
dc.contributor.author | Ha, Hyung-Ho | - |
dc.contributor.author | Samanta, Animesh | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.date.accessioned | 2018-06-15T05:13:58Z | - |
dc.date.available | 2018-06-15T05:13:58Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0004-9425 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50239 | - |
dc.description.abstract | To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the C-C bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. | - |
dc.language | English | - |
dc.publisher | CSIRO PUBLISHING | - |
dc.relation.isPartOf | AUSTRALIAN JOURNAL OF CHEMISTRY | - |
dc.subject | SOLID-PHASE SYNTHESIS | - |
dc.subject | 1,3,5-TRIAZINE DERIVATIVES | - |
dc.subject | BIOLOGICAL EVALUATION | - |
dc.subject | CYANURIC CHLORIDE | - |
dc.subject | S-TRIAZINES | - |
dc.subject | INHIBITORS | - |
dc.subject | MOLECULES | - |
dc.subject | KINASE | - |
dc.subject | SERIES | - |
dc.subject | NMR | - |
dc.title | Novel Orthogonal Synthesis of a Tagged Combinatorial Triazine Library via Grignard Reaction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1071/CH09153 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | AUSTRALIAN JOURNAL OF CHEMISTRY, v.62, no.9, pp.1000 - 1006 | - |
dc.identifier.wosid | 000269853200009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1006 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1000 | - |
dc.citation.title | AUSTRALIAN JOURNAL OF CHEMISTRY | - |
dc.citation.volume | 62 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-70349339213 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | SOLID-PHASE SYNTHESIS | - |
dc.subject.keywordPlus | 1,3,5-TRIAZINE DERIVATIVES | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | CYANURIC CHLORIDE | - |
dc.subject.keywordPlus | S-TRIAZINES | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | SERIES | - |
dc.subject.keywordPlus | NMR | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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