Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries
SCIE
SCOPUS
- Title
- Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries
- Authors
- Li, Qian; Ndonye, Rachel M.; Illarionov, Petr A.; Yu, Karl O. A.; Jerud, Elliot S.; Diaz, Kristine; Bricard, Gabriel; Porcelli, Steven A.; Besra, Gurdyal S.; Chang, Young-Tae; Howell, Amy R.
- Date Issued
- 2007-11
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Two 60+-membered libraries of (alpha-galactosylceramides have been prepared by reactions between activated ester resins and two core, fully deprotected galactosylated sphingoid bases. The libraries were evaluated for their ability to stimulate CD1d-restricted NKT cells, using in vitro stimulation of a murine NKT cell hybridoma line and for their ability to induce the expansion of NKT cells from peripheral blood mononuclear cells (PBMC of a normal human subject. bur results showed that many compounds constructed on a C18-phytosphingosine base had significant stimulatory activity in both assays. Because no. product purification was required, this approach is particularly attractive as a method for rapid synthesis of large libraries of potential immunomodulatory glycosylceramides.
- Keywords
- KILLER T-CELLS; NONOBESE DIABETIC MICE; NKT CELLS; ANTITUMOR ACTIVITIES; ACTIVATION; PREVENTS; RECOGNITION; RESPONSES; CD1; ANTIGENS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50248
- DOI
- 10.1021/cc070057i
- ISSN
- 1520-4766
- Article Type
- Article
- Citation
- JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 9, no. 6, page. 1084 - 1093, 2007-11
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.