Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin
SCIE
SCOPUS
- Title
- Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin
- Authors
- Min, Jaeki; Lee, Jae Wook; Ahn, Young-Hoon; Chang, Young-Tae
- Date Issued
- 2007-11
- Publisher
- AMER CHEMICAL SOC
- Abstract
- The combinatorial fluorescent dapoxyl dye library was prepared by both solution- and solid-phase synthesis, generating 80 unique dapoxyl derivatives. A fluorescence-based screening toward human serum albumin (HSA) found one highly sensitive HSA binder (A41-S) with over 55-fold intensity,change. Displacement assay showed the selective binding of A41-S to the site I of HSA, addressing its potential to be 4 highly selective and sensitive HSA probe.
- Keywords
- DRUG-BINDING-SITES; FLUORESCENT-PROBE; PROTEIN-BINDING; OXAZOLES; SENSORS; ACIDS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50249
- DOI
- 10.1021/cc0700546
- ISSN
- 1520-4766
- Article Type
- Article
- Citation
- JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 9, no. 6, page. 1079 - 1083, 2007-11
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