Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
SCIE
SCOPUS
- Title
- Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
- Authors
- Er, Jun Cheng; Vendrell, Marc; Tang, Mui Kee; Zhai, Duanting; Chang, Young-Tae
- Date Issued
- 2013-09
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites.
- Keywords
- LIGAND-BINDING PROPERTIES; BODIPY LIBRARY; CO-BINDING; F-19 NMR; PROBE; SPECIFICITY; SENSOR
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50317
- DOI
- 10.1021/co400060b
- ISSN
- 2156-8952
- Article Type
- Article
- Citation
- ACS COMBINATORIAL SCIENCE, vol. 15, no. 9, page. 452 - 457, 2013-09
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- There are no files associated with this item.
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