DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peng, Juanjuan | - |
dc.contributor.author | Samanta, Animesh | - |
dc.contributor.author | Zeng, Xiao | - |
dc.contributor.author | Han, Sanyang | - |
dc.contributor.author | Wang, Lu | - |
dc.contributor.author | Su, Dongdong | - |
dc.contributor.author | Loong, Daniel Teh Boon | - |
dc.contributor.author | Kang, Nam-Young | - |
dc.contributor.author | Park, Sung-Jin | - |
dc.contributor.author | All, Angelo Homayoun | - |
dc.contributor.author | Jiang, Wenxuan | - |
dc.contributor.author | Yuan, Lin | - |
dc.contributor.author | Liu, Xiaogang | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.date.accessioned | 2018-06-15T05:19:45Z | - |
dc.date.available | 2018-06-15T05:19:45Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50357 | - |
dc.description.abstract | Drug toxicity is a long-standing concern of modern medicine. A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO-. Conventional blood tests fail to offer real-time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore-conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore. ONOO- can readily bleach the chromophore and thus recover the luminescence, the presence of ONOO- in the liver leads to fast restoring of the near-infrared emission. Taking advantages of the high tissue-penetration capability of near-infrared excitation/emission, these nanoprobes achieve real-time monitoring of hepatotoxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.subject | UP-CONVERSION NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | PROBES | - |
dc.subject | LIVER | - |
dc.subject | PEROXYNITRITE | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | THERAPY | - |
dc.subject | SURFACE | - |
dc.title | Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/anie.201612020 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.56, no.15, pp.4165 - 4169 | - |
dc.identifier.wosid | 000397599500011 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 4169 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 4165 | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 56 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-85015328857 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 32 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | UP-CONVERSION NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | PEROXYNITRITE | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordAuthor | biosensors | - |
dc.subject.keywordAuthor | fluorescent probes | - |
dc.subject.keywordAuthor | hepatotoxicity | - |
dc.subject.keywordAuthor | nanotechnology | - |
dc.subject.keywordAuthor | paracetamol | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.