DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peng, Juanjuan | - |
dc.contributor.author | Xu, Wang | - |
dc.contributor.author | Teoh, Chai Lean | - |
dc.contributor.author | Han, Sanyang | - |
dc.contributor.author | Kim, Beomsue | - |
dc.contributor.author | Samanta, Animesh | - |
dc.contributor.author | Er, Jun Cheng | - |
dc.contributor.author | Wang, Lu | - |
dc.contributor.author | Yuan, Lin | - |
dc.contributor.author | Liu, Xiaogang | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.date.accessioned | 2018-06-15T05:21:05Z | - |
dc.date.available | 2018-06-15T05:21:05Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50386 | - |
dc.description.abstract | Development of highly sensitive and selective sensing systems of divalent zinc ion (Zn2+) in organisms has been a growing interest in the past decades owing to its pivotal role in cellular metabolism, apoptosis, and neurotransmission. Herein, we report the rational design and synthesis of a Zn2+ fluorescent-based probe by assembling lanthanide-doped upconversion nanoparticles (UCNPs) with chromophores. Specifically, upconversion luminescence (UCL) can be effectively quenched by the chromophores on the surface of nanoparticles via a fluorescence resonant energy transfer (FRET) process and subsequently recovered upon the addition of Zn2+, thus allowing for quantitative monitoring of Zn2+. Importantly, the sensing system enables detection of Zn2+ in real biological samples. We demonstrate that this chromophoreUCNP nanosystem is capable of implementing an efficient in vitro and in vivo detection of Zn2+ in mouse brain slice with Alzheimers disease and zebrafish, respectively. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.subject | CORE-SHELL NANOPARTICLES | - |
dc.subject | UPCONVERTING NANOPARTICLES | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | FLUORESCENT SENSORS | - |
dc.subject | SELECTIVE DETECTION | - |
dc.subject | CYANIDE ANIONS | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | LUMINESCENT | - |
dc.subject | PROBE | - |
dc.subject | ALZHEIMERS | - |
dc.title | High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja5115248 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.137, no.6, pp.2336 - 2342 | - |
dc.identifier.wosid | 000349807000035 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2342 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2336 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 137 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-84923253099 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 118 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CORE-SHELL NANOPARTICLES | - |
dc.subject.keywordPlus | UPCONVERTING NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | FLUORESCENT SENSORS | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | CYANIDE ANIONS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | LUMINESCENT | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordPlus | ALZHEIMERS | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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