Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
SCIE
SCOPUS
- Title
- Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
- Authors
- Park, S.; Lee, S.; Lee, C.-G.; Park, G.Y.; Hong, H.; Lee, J.-S.; Kim, Y.M.; Lee, S.B.; Hwang, D.; Choi, Y.S.; Fryer, J.D.; Im, S.-H.; Lee, S.-W.; Lee, Y.
- Date Issued
- 2017-07
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T(FH)) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of T(FH) cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null T(FH) cells and knockdown of Etv5 suppresses the enhanced T(FH) cell differentiation in Cic-deficient CD4+ T cells, suggesting that Etv5 is a critical CIC target gene in T(FH) cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC-ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates T(FH) cell development and autoimmunity. ? The Author(s) 2017.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50482
- DOI
- 10.1038/ncomms16037
- ISSN
- 2041-1723
- Article Type
- Article
- Citation
- Nature Communications, vol. 8, page. 10637, 2017-07
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