RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. Elegans
SCIE
SCOPUS
- Title
- RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. Elegans
- Authors
- Son, Heehwa G.; Seo, Mihwa; Ham, Seokjin; Hwang, Wooseon; Lee, Dongyeop; An, Seon Woo A.; Artan, Murat; Seo, Keunhee; Kaletsky, Rachel; Arey, Rachel N.; Ryu, Youngjae; Ha, Chang Man; Kim, Yoon Ki; Murphy, Coleen T.; Roh, Tae-Young; Nam, Hong Gil; Lee, Seung-Jae V.
- Date Issued
- 2017-03
- Publisher
- Nature Publishing Group
- Abstract
- Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. Elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations. ? The Author(s) 2017.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50542
- DOI
- 10.1038/ncomms14749
- ISSN
- 2041-1723
- Article Type
- Article
- Citation
- Nature Communications, vol. 8, no. 14749, 2017-03
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