Targeted Hyaluronate-Hollow Gold Nanosphere Conjugate for Anti-Obesity Photothermal Lipolysis
SCIE
SCOPUS
- Title
- Targeted Hyaluronate-Hollow Gold Nanosphere Conjugate for Anti-Obesity Photothermal Lipolysis
- Authors
- LEEJEONGHO; Jeong, Hyeon Seon; Lee, Dong Hyun; Beack, Songeun; Kim, Taeyeon; Lee, Geon-Hui; Park, Won Chan; Kim, Chulhong; Kim, Ki Su; Hahn, Sei Kwang
- Date Issued
- 2017-12
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Obesity is associated with the risk of developing several severe diseases, such as metabolic disorder, diabetes, and heart diseases. Despite wide investigation and trials, a noninvasive obesity therapy is still an important medical unmet need, targeting the abnormal adipose tissue. Here, we developed hyaluronate hollow gold nanosphere adipocyte-targeting peptide (HA-HAuNS-ATP) conjugates for the photothermal ablation of adipose tissues. The HA-HAuNS-ATP conjugate could be noninvasively delivered into the skin and effectively target to adipocytes in the subcutaneous. With near-infrared laser illumination, HA-HAuNS-ATP conjugate enabled highly effective photothermal ablation of adipose tissues in C57BL/6 obesity mice. The photoacoustic imaging confirmed the successful transdermal delivery and the photothermal lipolysis of HA-HAuNS-ATP conjugate. Taken together, the transdermal HA-HAuNS-ATP conjugate might have a great potential for noninvasive photothermal lipolysis.
- Keywords
- TRANSDERMAL DRUG-DELIVERY; ABLATION THERAPY; ADIPOSE-TISSUE; SKIN-CANCER; OBESITY; NANOPARTICLES; COMPLEX; RISK
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50663
- DOI
- 10.1021/acsbiomaterials.7b00549
- ISSN
- 2373-9878
- Article Type
- Article
- Citation
- ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 3, no. 12, page. 3646 - 3653, 2017-12
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