DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Wook | - |
dc.contributor.author | Chan, Clement T.Y. | - |
dc.contributor.author | Slomovic, Shimyn | - |
dc.contributor.author | Collins, James J. | - |
dc.date.accessioned | 2018-07-16T09:40:57Z | - |
dc.date.available | 2018-07-16T09:40:57Z | - |
dc.date.created | 2018-07-02 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1552-4450 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/91956 | - |
dc.description.abstract | The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Nature Chemical Biology | - |
dc.title | Next-generation biocontainment systems for engineered organisms | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41589-018-0056-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature Chemical Biology, v.14, no.6, pp.530 - 537 | - |
dc.identifier.wosid | 000435445100008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 537 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 530 | - |
dc.citation.title | Nature Chemical Biology | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Wook | - |
dc.identifier.scopusid | 2-s2.0-85047020981 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SEQUENCE-SPECIFIC ANTIMICROBIALS | - |
dc.subject.keywordPlus | SYNTHETIC MICROBIAL COMMUNITIES | - |
dc.subject.keywordPlus | RECOMBINANT DNA-MOLECULES | - |
dc.subject.keywordPlus | TOXIN-ANTITOXIN SYSTEMS | - |
dc.subject.keywordPlus | BIOLOGICAL CONTAINMENT | - |
dc.subject.keywordPlus | ASILOMAR CONFERENCE | - |
dc.subject.keywordPlus | GENOME SAFEGUARDS | - |
dc.subject.keywordPlus | GENE DRIVES | - |
dc.subject.keywordPlus | CORN POLLEN | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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