DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyunjoo | - |
dc.contributor.author | Jo, Eun Byeol | - |
dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Yang, Heung Mo | - |
dc.contributor.author | Kim, You Min | - |
dc.contributor.author | Sung, Young Chul | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Hong, Doopyo | - |
dc.contributor.author | Park, Hyojun | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Kim, Sung Joo | - |
dc.date.accessioned | 2018-07-16T09:46:16Z | - |
dc.date.available | 2018-07-16T09:46:16Z | - |
dc.date.created | 2017-09-14 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1465-3249 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/92037 | - |
dc.description.abstract | Background aims. Major challenges in de-differentiated liposarcoma (DDLPS) therapy are the high rate of sequential recurrence (>80%) and metastasis (20-30%) following surgical removal. However, well-defined therapeutic strategies for this rare malignancy are lacking and are critically needed. Methods. We investigated a new approach to DDLPS therapy with mesenchymal stromal cells expressing herpes simplex virus thymidine kinase (MSC-TK). In an effort to evaluate this efficacy, in vitro cytotoxicity of MSC-TK against DDLPS cells was analyzed using an apoptosis assay. For pre-clinical study, the MSC-TK induced reduction in recurrence and metastasis was validated in a recurrent DDLPS model after the macroscopic complete resection and lung metastasis DDLPS model. Results. MSC-TK induced apoptosis in DDLPS cells by bystander effects via gap junction intracellular communication (GJIC) of toxic ganciclovir (GCV). Recurrent DDLPS models following no residual tumor/microscopic tumor resection and lung metastasis DDLPS models were established, which suggested clinical relevance. MSC-TK markedly reduced locoregional recurrence rates and prolonged recurrence-free survival, thus increasing overall survival in the recurrent DDLPS model. MSC-TK followed by GCV treatment yielded a statistically significant reduction in early and advanced-stage lung metastasis. Discussion. This therapeutic strategy may serve as an alternative or additional strategy by applying MSC-TK to target residual tumors following surgical resection, thus reducing local relapse and metastasis in these patients. | - |
dc.language | English | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.relation.isPartOf | CYTOTHERAPY | - |
dc.subject | SOFT-TISSUE SARCOMAS | - |
dc.subject | STEM-CELLS | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | SUICIDE GENE | - |
dc.subject | HSV-TK | - |
dc.subject | TRAIL | - |
dc.subject | CISPLATIN | - |
dc.subject | PATHWAY | - |
dc.subject | GLIOMA | - |
dc.title | Therapeutic strategies for locally recurrent and metastatic de-differentiated liposarcoma with herpes simplex virus-thymidine kinase-expressing mesenchymal stromal cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jcyt.2017.05.008 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CYTOTHERAPY, v.19, no.9, pp.1035 - 1047 | - |
dc.identifier.wosid | 000408401900003 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1047 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1035 | - |
dc.citation.title | CYTOTHERAPY | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Kim, Su Jin | - |
dc.contributor.affiliatedAuthor | Sung, Young Chul | - |
dc.identifier.scopusid | 2-s2.0-85026309722 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SOFT-TISSUE SARCOMAS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | SUICIDE GENE | - |
dc.subject.keywordPlus | HSV-TK | - |
dc.subject.keywordPlus | TRAIL | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordAuthor | de-differentiated liposarcoma | - |
dc.subject.keywordAuthor | herpes simplex virus-thymidine kinase | - |
dc.subject.keywordAuthor | locoregional recurrence | - |
dc.subject.keywordAuthor | mesenchymal stromal cells | - |
dc.subject.keywordAuthor | metastasis | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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