DC Field | Value | Language |
---|---|---|
dc.contributor.author | JAE-HO CHO | - |
dc.contributor.author | HEE-OK KIM | - |
dc.contributor.author | KYLIE WEBSTER | - |
dc.contributor.author | MAINTHAN PALENDIRA | - |
dc.contributor.author | BUMSUK HAHM | - |
dc.contributor.author | KYU-SIK KIM | - |
dc.contributor.author | CECILE KING | - |
dc.contributor.author | STUART TANGYE | - |
dc.contributor.author | Sprent, J | - |
dc.date.accessioned | 2018-10-04T05:58:07Z | - |
dc.date.available | 2018-10-04T05:58:07Z | - |
dc.date.created | 2011-08-05 | - |
dc.date.issued | 2011-07-07 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/92458 | - |
dc.description.abstract | Immune responses lead to expression of immunoregulatory molecules on T cells, including natural killer (NK) receptors, such as CD94/NKG2A on CD8(+) T cells; these receptors restrain CD8(+) responses, thereby preventing T-cell exhaustion in chronic infections and limiting immunopathology. Here, we examined the requirements for inducing CD94/NKG2A on T cells responding to antigen. In vitro, moderate induction of CD94/NKG2A expression occurred after exposure of naive CD8(+) (but not CD4(+)) cells to CD3 ligation or specific peptide. Surprisingly, expression was inhibited by CD28/B7 costimulation. Such inhibition applied only to CD94/NKG2A and not other NK receptors (NKG2D) and was mediated by IL-2. Inhibition by IL-2 occurred via a NFAT cell-independent component of the calcineurin pathway, and CD94/NKG2A induction was markedly enhanced in the presence of calcineurin blockers, such as FK506 or using calcineurin-deficient T cells, both in vitro and in vivo. In addition to CD28-dependent inhibition by IL-2, CD94/NKG2A expression was impaired by several other cytokines (IL-4, IL-23, and transforming growth factor-beta) but enhanced by others (IL-6, IL-10, and IL-21). The complex interplay between these various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo. (Blood. 2011;118(1):116-128) | - |
dc.language | English | - |
dc.publisher | American Society of Hematology | - |
dc.relation.isPartOf | BLOOD | - |
dc.title | Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8(+) T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1182/BLOOD-2010-11-317396 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BLOOD, v.1, no.1, pp.116 - 128 | - |
dc.identifier.wosid | 000292505900018 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 128 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 116 | - |
dc.citation.title | BLOOD | - |
dc.citation.volume | 1 | - |
dc.contributor.affiliatedAuthor | Sprent, J | - |
dc.identifier.scopusid | 2-s2.0-79960142402 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | RECEPTORS CD94/NKG2A | - |
dc.subject.keywordPlus | INHIBITORY RECEPTORS | - |
dc.subject.keywordPlus | ANTIGEN RECEPTOR | - |
dc.subject.keywordPlus | MOLECULE QA-1(B) | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | CYCLOSPORINE-A | - |
dc.subject.keywordPlus | NK CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
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