Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
SCIE
SCOPUS
- Title
- Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
- Authors
- Sprent, J; Charles Surh
- Date Issued
- 2011-06
- Publisher
- NATURE IMMUNOLOGY
- Abstract
- Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an intensity just below that required to induce entry into the cell cycle. Costimulation from higher concentrations of IL-7 and other common gamma-chain cytokines can induce T cells to undergo homeostatic proliferation and conversion into cells with a memory phenotype; many of these memory phenotype cells may be the progeny of cells responding to self antigens. The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/92461
- DOI
- 10.1038/NI.2018
- ISSN
- 1529-2908
- Article Type
- Article
- Citation
- NATURE IMMUNOLOGY, vol. 12, no. 6, page. 478 - 484, 2011-06
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