DC Field | Value | Language |
---|---|---|
dc.contributor.author | Terabe, F | - |
dc.contributor.author | Fujimoto, M | - |
dc.contributor.author | Serada, S | - |
dc.contributor.author | Shinzaki, S | - |
dc.contributor.author | Iijima, H | - |
dc.contributor.author | Tsujii, M | - |
dc.contributor.author | Hayashi, N | - |
dc.contributor.author | Nomura, S | - |
dc.contributor.author | Kawahata, H | - |
dc.contributor.author | Jang, MH | - |
dc.contributor.author | Miyasaka, M | - |
dc.contributor.author | Mihara, M | - |
dc.contributor.author | Ohsugi, Y | - |
dc.contributor.author | Kishimoto, T | - |
dc.contributor.author | Naka, T | - |
dc.date.accessioned | 2018-10-04T05:58:26Z | - |
dc.date.available | 2018-10-04T05:58:26Z | - |
dc.date.created | 2011-08-05 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 1078-0998 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/92465 | - |
dc.description.abstract | Background: The efficacy of anti-tumor necrosis factor monoclonal antibody (anti-TNF mAb) for Crohn's disease (CD) is well established, and anti-interleukin-6 receptor (anti-IL-6R) mAb has also been reported to be effective in CD. It is, however, unclear if the efficacy and mechanisms of both agents are different in CD therapy. Methods: Using an adoptive transfer colitis model, we compared the efficacy of anti-IL-6R mAb, anti-TNF mAb, and TNF receptor-Fc fusion protein (TNFR-Fc), and their modes of action on CD4(+) T cells. We also investigated the role of Th1 and Th17 cells in colitis using the same model. Results: The histological scores for the anti-IL-6R mAb and anti-TNF mAb groups but not for TNFR-Fc group were much lower than that for the control group, and the score was the lowest for the anti-IL-6R mAb group. The frequency of proliferating CD4(+) T cells was reduced in anti-IL-6R mAb and anti-TNF mAb groups, but not in the TNFR-Fc group, whereas the frequency of apoptotic CD4(+) T cells was similar in all groups. Anti-IL-6R mAb suppressed the induction of Th17 cells and increased the frequency of lamina propria regulatory T cells, whereas anti-TNF mAb exerted no influence on CD4(+) T-cell differentiation. A deficiency in interferon-gamma and/or IL-17 in CD4(+) T cells reduced the severity of colitis. Conclusions: Our findings suggest that suppression of the proliferation of pathogenic CD4(+) T cells is the major mode of action of biological agents for colitis therapy. Anti-IL-6R mAb might have benefits in CD patients with Th17 dominance and impaired Treg frequency. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | INFLAMMATORY BOWEL DISEASES | - |
dc.title | Comparative Analysis of the Effects of Anti-IL-6 Receptor mAb and Anti-TNF mAb Treatment on CD4(+) T-cell Responses in Murine Colitis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/IBD.21384 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | INFLAMMATORY BOWEL DISEASES, v.17, no.2, pp.491 - 502 | - |
dc.identifier.wosid | 000287116500001 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 502 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 491 | - |
dc.citation.title | INFLAMMATORY BOWEL DISEASES | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Jang, MH | - |
dc.identifier.scopusid | 2-s2.0-78651310474 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | ACTIVE CROHNS-DISEASE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | MEDIATED INTESTINAL INFLAMMATION | - |
dc.subject.keywordPlus | SODIUM-INDUCED COLITIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | DEPENDENT COLITIS | - |
dc.subject.keywordAuthor | interleukin-6 | - |
dc.subject.keywordAuthor | tumor necrosis factor | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | Th17 cells | - |
dc.subject.keywordAuthor | Treg cells | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
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