표적형 약물 전달 브러쉬 원형 블록공중합체 마이셀의 구조 및 특성

Abstract

The field of drug delivery systems (DDS) is among the pinnacles of modern civilization’s achievements. The pursuit of enhanced quality of life and prolonged lifespan has yield a wide arrays of vaccines, drugs, pharmaceutics, genes, and biomolecules, and a vast database of pathogens and diseases. As the advancement from the current medicinal technology, carrier-based drug delivery systems with high performance targeting abilities are under development. In particular, polymeric micelles are known to be the suitable candidates for entering the practical medical applications but they suffer from limited control over micelle structural stability, size and size distribution, drug loading capacity, and targeting efficiency. These drawbacks are preventing DDS micelles from entering clinical trials and further stages of applications. This particular research aims to address the aforementioned drawbacks by conducting a fundamental study on the impact of polymer topology to micellar structural stability and size control, and developing high performance micelles of a novel amphiphilic brush cyclic block copolymer system with chemically conjugated drug molecules and ligand molecules enabling active targeting abilities. Moreover, the novel brush cyclic block copolymer system is intended to form nanoscale polymeric micelles with unimodal size distribution, high drug loading capacity, and high targeting efficiency, thereby addressing the drawbacks of micellar DDS to enable practical medicinal applications and practice. Currently, the research has succeeded in conducting the aforementioned fundamental study, in which the cyclic topology does indeed function as a beneficial factor in stabilizing polymer micelles in solution. Also, the synthesis of amphiphilic brush cyclic block copolymer system with chemically conjugated paclitaxel molecule and galactosamine molecules is ongoing. The reference amphiphilic brush cyclic block copolymer system without paclitaxel molecule and galactosamine molecules, the amphiphilic brush cyclic block copolymer system with paclitaxel molecule, and amphiphilic brush cyclic block copolymer system with galactosamine molecules were synthesized for the investigation of the impact of the presence of drug and ligand molecule upon micellization behavior. The structural characterization of the three copolymers are ongoing and require further research to comprehend their structural characteristics.