DC Field | Value | Language |
---|---|---|
dc.contributor.author | Verma, Ravi | - |
dc.contributor.author | LEE, CHANGHON | - |
dc.contributor.author | Jeun, Eun-Ji | - |
dc.contributor.author | JAEU, YI | - |
dc.contributor.author | Kim, Kwang Soon | - |
dc.contributor.author | Ghosh, Ambarnil | - |
dc.contributor.author | BYUN, SEOHYUN | - |
dc.contributor.author | Lee, Choong-Gu | - |
dc.contributor.author | Kang, Hye-Ji | - |
dc.contributor.author | Kim, Gi-Cheon | - |
dc.contributor.author | Jun, Chang-Duk | - |
dc.contributor.author | Jan, Gwenael | - |
dc.contributor.author | Suh, Chang-Hee | - |
dc.contributor.author | Jung, Ju-Yang | - |
dc.contributor.author | Sprent, Jonathan | - |
dc.contributor.author | Rudra, Dipayan | - |
dc.contributor.author | De Castro, Cristina | - |
dc.contributor.author | Molinaro, Antonio | - |
dc.contributor.author | SURH, CHARLES D | - |
dc.contributor.author | IM, SIN HYEOG | - |
dc.date.accessioned | 2018-12-04T01:52:28Z | - |
dc.date.available | 2018-12-04T01:52:28Z | - |
dc.date.created | 2018-11-17 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94274 | - |
dc.description.abstract | Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3+ T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3+ Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface β-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes. | - |
dc.language | English | - |
dc.publisher | AAAS | - |
dc.relation.isPartOf | Science immunology | - |
dc.title | Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciimmunol.aat6975 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Science immunology, v.3, no.28, pp.6975 | - |
dc.identifier.wosid | 000449233400004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 6975 | - |
dc.citation.title | Science immunology | - |
dc.citation.volume | 3 | - |
dc.contributor.affiliatedAuthor | LEE, CHANGHON | - |
dc.contributor.affiliatedAuthor | JAEU, YI | - |
dc.contributor.affiliatedAuthor | BYUN, SEOHYUN | - |
dc.contributor.affiliatedAuthor | SURH, CHARLES D | - |
dc.contributor.affiliatedAuthor | IM, SIN HYEOG | - |
dc.identifier.scopusid | 2-s2.0-85055076579 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | ARTICLE | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR FOXP3 | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | INTESTINAL INFLAMMATION | - |
dc.subject.keywordPlus | HUMAN MICROBIOTA | - |
dc.subject.keywordPlus | COMMENSAL | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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