DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Chang Sup | - |
dc.contributor.author | Heo, Hye Ryoung | - |
dc.contributor.author | Seo, Jeong Hyun | - |
dc.contributor.author | Cha, Hyung Joon | - |
dc.date.accessioned | 2019-04-07T15:02:47Z | - |
dc.date.available | 2019-04-07T15:02:47Z | - |
dc.date.created | 2019-01-16 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/95329 | - |
dc.description.abstract | A functional glycan chip combined with on-chip enzymatic glycosylation was developed to prepare complex glycan sources and to apply glycan-involved applications simultaneously. GM3 trisaccharide, GM2 tetrasaccharide, and GM1 pentasaccharide were successfully directly biosynthesized on lactose-immobilized surfaces through three consecutive glycosyltransferase reactions along with small amounts of enzymes and donors, without any additional processes. Biosynthesized GM1 pentasaccharide-related complex glycans were demonstrated to provide information on the substrate specificity of whole cholera toxin. Thus, the proposed on-chip glycan biosynthesis system can provide a new direction toward obtaining complex glycan sources and complex glycan-involved applications such as glycan-protein interaction analysis and glycan biomarker-based diagnosis. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.title | On-chip biosynthesis of GM1 pentasaccharide-related complex glycans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c8cc06526h | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.55, no.1, pp.71 - 74 | - |
dc.identifier.wosid | 000453549600009 | - |
dc.citation.endPage | 74 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 71 | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 55 | - |
dc.contributor.affiliatedAuthor | Cha, Hyung Joon | - |
dc.identifier.scopusid | 2-s2.0-85058691411 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SIALYLTRANSFERASE | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | MICROARRAYS | - |
dc.subject.keywordPlus | CHEMICAL-SYNTHESIS | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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