DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Jiaquan | - |
dc.contributor.author | Lee, Jong-Bong | - |
dc.contributor.author | Fishel, Richard | - |
dc.date.accessioned | 2019-04-07T15:56:04Z | - |
dc.date.available | 2019-04-07T15:56:04Z | - |
dc.date.created | 2018-12-04 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/95516 | - |
dc.description.abstract | DNA mismatch repair (MMR) is a DNA excision-resynthesis process that principally enhances replication fidelity. Highly conserved MutS (MSH) and MutL (MLH/PMS) homologs initiate MMR and in higher eukaryotes act as DNA damage sensors that can trigger apoptosis. MSH proteins recognize mismatched nucleotides, whereas the MLH/PMS proteins mediate multiple interactions associated with downstream MMR events including strand discrimination and strand-specific excision that are initiated at a significant distance from the mismatch. Remarkably, the biophysical functions of the MLH/PMS proteins have been elusive for decades. Here we consider recent observations that have helped to define the mechanics of MLH/PMS proteins and their role in choreographing MMR. We highlight the stochastic nature of DNA interactions that have been visualized by single-molecule analysis and the plasticity of protein complexes that employ thermal diffusion to complete the progressions of MMR. (C) 2018 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.title | Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jmb.2018.05.039 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.430, no.22, pp.4456 - 4468 | - |
dc.identifier.wosid | 000449242300003 | - |
dc.citation.endPage | 4468 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 4456 | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 430 | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Bong | - |
dc.identifier.scopusid | 2-s2.0-85048724734 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Review | - |
dc.subject.keywordPlus | CELL NUCLEAR ANTIGEN | - |
dc.subject.keywordPlus | C-TERMINAL DOMAIN | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI MUTS | - |
dc.subject.keywordPlus | NICKED CIRCULAR DNA | - |
dc.subject.keywordPlus | HUMAN EXONUCLEASE-I | - |
dc.subject.keywordPlus | BETA-SLIDING-CLAMP | - |
dc.subject.keywordPlus | HELICASE-II | - |
dc.subject.keywordPlus | AUXILIARY PROTEIN | - |
dc.subject.keywordPlus | POLYMERASE-DELTA | - |
dc.subject.keywordPlus | ATPASE ACTIVITY | - |
dc.subject.keywordAuthor | mismatch-repair | - |
dc.subject.keywordAuthor | single-molecule biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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