Electrical force-based continuous cell lysis and sample separation techniques for development of integrated microfluidic cell analysis system: A review

Abstract

Cell lysis and the separation of intracellular components are key steps in the analysis of intracellular components. Advances in micro-electro-mechanical system (MEMS) technologies have prompted a number of investigations into the potential applications of microfluidics to the development of cell lysis and sample separation methods. The electrical force is considered to have excellent potential for parallelizing and automating cell lysis and sample separation methods. In this review, we focus on research works related to electrical force based continuous cell lysis and sample separation techniques. We provide brief explanations of the major developed techniques and summarize their advantages and limitations with respect to their applicability as a part of integrated microfluidic cell analysis system.